Store-operated calcium entry enhances the polarization and chemotaxis of neutrophils in the peripheral venous blood of patients with bronchial asthma by upregulating ERM protein.

Background: Neutrophils can be rapidly recruited and are largely abundant in the airways of patients with asthma. However, whether the polarization and chemotaxis of neutrophils in patients with asthma are abnormal, and the underlying mechanisms, have not been clarified. Pseudopods formation is the initial step of neutrophils' polarization, ezrin, radixin and moesin (ERM) play an important role in the polarization of neutrophils.

Abnormal neutrophil polarization in chronic obstructive pulmonary disease and how cigarette smoke extracts attract neutrophils.

Background: Airway inflammation produced by neutrophils is a critical factor in the development of chronic obstructive pulmonary disease (COPD). Poor or excessive neutrophil polarization and chemotaxis may lead to pathogen accumulation and tissue damage. However, it is unclear how cigarette smoke extract (CSE) attracts neutrophils and to what extent COPD is affected by the improper polarization of these abnormal neutrophils.

Terahertz spectroscopy of citrate Salts: Effects of crystalline state and crystallization water.

Citrate salts are widely used as food additives and medicines for health and treatment. Accurate and fast detection of citrate salts is most important in food industry and medicine health. In this work, terahertz (THz) time-domain spectroscopy was used to detect and analyze different citrate salts and differentiate their crystalline hydrates.

Fine-Scale Space-Time Cluster Detection of COVID-19 in Mainland China Using Retrospective Analysis.

Exploring spatio-temporal patterns of disease incidence can help to identify areas of significantly elevated or decreased risk, providing potential etiologic clues. The study uses the retrospective analysis of space-time scan statistic to detect the clusters of COVID-19 in mainland China with a different maximum clustering radius at the family-level based on case dates of onset. The results show that the detected clusters vary with the clustering radius.

Study of the Effects of Air Pollutants on Human Health Based on Baidu Indices of Disease Symptoms and Air Quality Monitoring Data in Beijing, China.

There is an increasing body of evidence showing the impact of air pollutants on human health such as on the respiratory, and cardio- and cerebrovascular systems. In China, as people begin to pay more attention to air quality, recent research focused on the quantitative assessment of the effects of air pollutants on human health. To assess the health effects of air pollutants and to construct an indicator placing emphasis on health impact, a generalized additive model was selected to assess the health burden caused by air pollution.

Medical resource preparation and allocation for humanitarian assistance based on module organization.

Background: This research aims to associate the allocation of medical resources with the function of the modular organization and the possible needs for humanitarian assistance missions.

Methods: The overseas humanitarian medical assistance mission, which was sent after a disaster on the hospital ship Peace Ark, part of China's People's Liberation Army (PLA) Navy, was considered as study model. The cases used for clustering and matching sample formation were randomly selected from the existing information related to Peace Ark's mission.

Transfection of bone marrow mesenchymal stem cells using green fluorescence protein labeled hVEGF165 recombinant plasmid mediated by liposome.

Objective: To study the role of bone marrow mesenchymal stem cells (BMSCs) in construction of vascularized engineered tissue.

Methods: hVEGF165 was amplified via RT-PCR before recombinant with pShuttle- green fluorescence protein;green fluorescent protein (GFP)-CMV. Then the recombinant shuttle plasmid was transfected into BMSCs with Lipofectamine(TM) 2000 for packaging and amplifying.

Risk analysis for the highly pathogenic avian influenza in Mainland China using meta-modeling.

A logistic model was employed to correlate the outbreak of highly pathogenic avian influenza (HPAI) with related environmental factors and the migration of birds. Based on MODIS data of the normalized difference vegetation index, environmental factors were considered in generating a probability map with the aid of logistic regression. A Bayesian maximum entropy model was employed to explore the spatial and temporal correlations of HPAI incidence.

The novel H1N1 Influenza A global airline transmission and early warning without travel containments.

A novel influenza A (H1N1) has been spreading worldwide. Early studies implied that international air travels might be key cause of a severe potential pandemic without appropriate containments. In this study, early outbreaks in Mexico and some cities of United States were used to estimate the preliminary epidemic parameters by applying adjusted SEIR epidemiological model, indicating transmissibility infectivity of the virus.

Simulation of the spread of infectious diseases in a geographical environment.

The study of mathematical models for the spread of infectious diseases is an important issue in epidemiology. Given the fact that most existing models cannot comprehensively depict heterogeneities (e.g.