Metabolomics revealed pharmacodynamic effects of aspirin and indobufen in patients after percutaneous transluminal angioplasty surgery.

Introduction: Aspirin and indobufen are commonly used therapeutic drugs for the prevention of vascular restenosis (VR) after percutaneous transluminal angioplasty surgery. They both exhibited antiplatelet effects but molecular mechanisms underlying metabolic changes induced by them remain unclear.

Methods: In this study, we collected plasma samples from patients on aspirin medication ( = 5), patients on indobufen medication, patients with no medication after PTA, and healthy controls (CKs) ( = 5).

Numerical modeling of the effects of the shape and aspect ratio of 3D curved fiber on the percolation threshold and electrical conductivity of conductive polymer composites.

For designing conductive polymer composites (CPCs), understanding how the fiber curvature affects the percolation behavior of curved conductive fibers is essential for determining the effective electrical conductivity of the CPCs. In this work, CPCs were considered as a polymer matrix filled with the random packing of overlapped curved spherocylinders. The geometries of the curved spherocylinders were defined, and inter-curved spherocylinder contact-detecting and system-spanning fiber cluster searching algorithms were developed.

Critical role of water conditions in the responses of autumn phenology of marsh wetlands to climate change on the Tibetan Plateau.

The Tibetan Plateau, housing 20% of China's wetlands, plays a vital role in the regional carbon cycle. Examining the phenological dynamics of wetland vegetation in response to climate change is crucial for understanding its impact on the ecosystem. Despite this importance, the specific effects of climate change on wetland vegetation phenology in this region remain uncertain.

Assessment of urinary podocalyxin as an alternative marker for urinary albumin creatinine ratio in early stage of diabetic kidney disease in older patients.

This study's objective is to evaluate the correlation relationship between Podocalyxin (PCX), an urinary marker of podocytes, urinary albumin-creatinine ratio (ACR) and the predictive value of PCX in the routine screen of early diabetic kidney disease (DKD) among older people. We also aimed to explore its prediction value despite of other metabolic factor and how PCX alters in the predictive power for early stage of diabetic nephropathy. In retrospective, 320 cases of older patients diagnosed with type 2 diabetes mellitus who met both inclusion and exclusion criteria were collected and divided with levels of urinary albumin, that is, normal albuminuria group, microalbuminuria group and healthy group.

A Universal Method for Modeling and Characterizing Non-Circular Packing Systems Based on -Point Correlation Functions.

A universal method for modeling and characterizing non-circular particles is developed. The -point correlation functions ( = 1, 2 and 3) are efficiently computed with a GPU parallel computing procedure. An algorithm for dynamic packing of impenetrable non-circular particles is developed based on the fast estimation of overlap information using a one-point correlation function.

Third-Order Effective Properties for Random-Packing Systems Using Statistical Micromechanics Based on a GPU Parallel Algorithm in Fast Computing -Point Correlation Functions.

Estimating the effective properties of a particulate system is the most direct way to understand its macroscopic performance. In this work, we accurately evaluate the third-order approximations involving the three-point microstructural parameter ζ, which can be calculated from a triple integral involving 1-, 2-, and 3-point correlation functions. A GPU-based parallel algorithm was developed for quickly computing the -point correlation functions, and the results agree well with analytical solutions.

Error Types of and Strategies on Learning Chinese Connectives: A Study on Chinese as a Second Language Learners' Writing.

The correct use of connectives has great influence on language learners' writing proficiency, while errors of connectives are common in foreign learners' interlanguages. This study examines the types of errors that occur in native English-speaking learners' Chinese writing, the possible causes for the errors, and the learners' consequent learning strategies. The present research adopted corpora investigation, questionnaire survey, and focus-group interviews to examine the error types, causes of identified errors, and related learning strategies.

Adaptive method for estimating information from a polarized skylight.

The acquisition and processing of skylight polarization information forms the cornerstone in modern navigation systems that are developed by imitating certain biological mechanisms. The accuracy of skylight polarization mode information plays a major part in improving the accuracy of polarized light navigation. This paper mainly focuses on developing a methodology that can avoid the error caused by the inaccurate rotation of the polarizer and manual readings from non-electrical equipment, when the time-sequence polarization measurement system is used to obtain the skylight polarization mode information.

Controversies in the application of corticosteroids for pediatric septic shock treatment: a preferred reporting items for systematic reviews and meta-analysis-compliant updated meta-analysis.

Objectives: Septic shock is the major cause of childhood mortality. However, the application of corticosteroids remains controversial. This work aimed to analyze the source of controversy based on existing data and recent randomized controlled trials by meta-analysis and to assess whether it can avoid these factors to guide clinical treatment.

lncRNA Oip5-as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR-29a to activate the SIRT1/AMPK/PGC1α pathway.

Objectives: Myocardial ischaemia/reperfusion (MI/R) injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanisms underlying MI/R injury are unclear. This study investigated the role of long non-coding RNA (lncRNA) Oip5-as1 in regulating mitochondria-mediated apoptosis during MI/R injury.

Breakfast prevalence of medical students is higher than students from nonmedical faculties in Inner Mongolia Medical University.

Background: Skipping breakfast is becoming common worldwide. Our previous studies showed that the breakfast prevalence was relatively low.

Methods: In three cross-sectional studies, breakfast prevalence in various populations in Inner Mongolia Medical University campus in 2011, 2013 and 2017 was investigated.

Improved Models of Imaging of Skylight Polarization Through a Fisheye Lens.

Researchers have found that some animals can use the skylight polarization pattern for navigation. It is also expected to use the skylight polarization pattern for human navigating in the near future. However, the challenge is that the need for a more accurate and efficient model of the imaging of skylight polarization is always felt.

Biomimetic chitosan-graft-polypeptides for improved adhesion in tissue and metal.

Inspired by the mussel foot protein and chitosan-based macromolecular adhesives, a series of chitosan-graft-polypeptides were synthesized by ring-opening polymerization of three N-carboxyanhydrides (NCAs) - 3,4-dihydroxyphenylalanine-N-carboxyanhydride (DOPA-NCA), cysteine-NCA (Cys-NCA) and arginine-NCA (Arg-NCA) - using partial-NH-protected chitosan as an initiator. These copolymers demonstrated good biodegradability and low cytotoxicity. The results of lap-shear adhesion test showed that the maximum lap-shear adhesion strength on the porcine skin and aluminum sheet were 195.

Multi-scale assessment of eco-hydrological resilience to drought in China over the last three decades.

Understanding to what extent can terrestrial ecosystems maintain their structure and functions and recover after being hit by drought is critical for sustainable ecosystem management and drought mitigation practices. This study assesses multi-scale (i.e.

Impacts of Chinese Grain for Green program and climate change on vegetation in the Loess Plateau during 1982-2015.

Remote sensing based vegetation index provides a practical method for the monitoring of vegetation dynamics at regional and global scales. Here, using a long-term remotely sensed normalized difference vegetation index (NDVI) dataset, we quantified the vegetation changes in the Loess Plateau (LP) over the last three decades (1982-2015), which includes the period before the Chinese"Grain for Green Program"(GGP) was launched (1982-1999), and the period after the GGP (1999-2015). The correlations between the NDVI and four climate related variables, i.

Norcantharidin combined with diamminedichloroplatinum inhibits tumor growth and cancerometastasis of hepatic carcinoma in murine.

Aim: Norcantharidin (NCTD) has been used as a clinical antineoplastic drug in China for several years, and diamminedichloroplatinum is a valuable clinical cancer chemotherapy agent. Here, we tried to investigate the effects of NCTD plus diamminedichloroplatinum on hepatic carcinoma in murine.

Materials And Methods: In vivo and in vitro investigations on anticancer effects of the two drugs were individually made.

All-in-one hyperbranched polypeptides for surgical adhesives and interventional embolization of tumors.

A series of hyperbranched, thermo-responsive and mussel-inspired polypeptides were synthesized and used for surgical adhesion, hemostasis and interventional embolization. These polypeptides showed excellent tissue-adhesive properties according to adhesive strength tests on porcine skin and bone in vitro, where the maximum lap-shear adhesion strength on porcine skin was 114.5 kPa and the maximum tensile adhesion strength on bone was 786 kPa.

CT, MRI, and F-18 FDG PET for the detection of non-small-cell lung cancer (NSCLC): A protocol for a network meta-analysis of diagnostic test accuracy.

Background: Non-small-cell lung cancer (NSCLC) is a rare cancer in lung carcinomas and has been widely known as a difficult curable disease among all the tumors. However, early detection of malignant potential in patients with NSCLC has still been a huge challenge all around the world. CT, MRI, and F-18 FDG PET are all considered as good tests for diagnosing malignant NSCLC efficiently, but no recommended suggestion presents that which test among the 3 is the prior one in diagnose.

Network pharmacology-based identification of major component of and its action mechanism for the treatment of acute myocardial infarction.

To decipher the mechanisms of for the treatment of acute myocardial infarction (AMI) using network pharmacology analysis. Databases were searched for the information on constituents, targets, and diseases. Cytoscape software was used to construct the constituent-target-disease network and screen the major targets, which were annotated with the DAVID (Database for Annotation, Visualization and Integrated Discovery) tool.

Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.

Objectives Angelica sinensis exerts various pharmacological effects, such as antioxidant and anti-apoptotic activity. This study aimed to investigate the active ingredients in A. sinensis with antioxidant properties and whether A.

Astragalus Saponins and Liposome Constitute an Efficacious Adjuvant Formulation for Cancer Vaccines.

Cancer vaccines mostly aim to induce cytotoxic T lymphocytes (CTLs) against tumors. An appropriate adjuvant is of fundamental importance for inducing cellular immune response. Since the antigen in particulate form is substantially more immunogenic than soluble form antigen, it is beneficial to interact with antigen-presenting cells membrane to induce robust CD8 T cell activation following vaccination.

Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma through p38-mediated reactive oxygen species generation.

The present study aimed to investigate the potential anticancer effect and mechanisms of salvianolic acid B on osteosarcoma. Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. Additionally, Salvianolic acid B also increased the level of reactive oxygen species (ROS) generation in the MG63 cells.