B-Modified Pd Cathodes for the Efficient Detoxification of Halogenated Antibiotics: Enhancing C-F Bond Breakage beyond Hydrodefluorination.

Halogenated antibiotics pose a great threat to aqueous environments because of their persistent biotoxicity from carbon-halogen bonds. Electrochemical reduction (ER) is an efficient technology for dehalogenation, but it still suffers from limited efficiencies in breaking C-F bonds. Herein, we present a strategy to enhance C-F cleavage and promote detoxification by loading benchmark palladium cathodes onto boron-doped carbon.

Three new antifungal phthalide derivatives from Cajanus cajan.

Three new phthalide derivatives, denominated Cajanthalides A, B and C (1-3), were identified from the leaves of Cajanus cajan. Their structures were meticulously elucidated through comprehensive analysis utilizing UV, IR, NMR (1D and 2D), HRESIMS, chiral analysis and DP4+ analysis. Notably, these new phthalide derivatives are present in racemic forms, with compounds 2 and 3 sharing identical planar structures.

Identification of blood-derived exosomal tumor RNA signatures as noninvasive diagnostic biomarkers for multi-cancer: a multi-phase, multi-center study.

Background: Cancer remains a leading global cause of mortality, making early detection crucial for improving survival outcomes. The study aims to develop a machine learning-enabled blood-derived exosomal RNA profiling platform for multi-cancer detection and localization.

Methods: In this multi-phase, multi-center study, we analyzed RNA from exosomes derived from peripheral blood plasma in 818 participants across eight cancer types during the discovery phase.

The connection between depression and frailty among older adults with obstructive sleep apnea: results from a multicenter cohort study.

Background: The rising rates of obstructive sleep apnea (OSA) and frailty among older adults are linked to higher mortality rates. Depression merges as a critical determinant associated with both OSA and frailty. This study investigates the impact of depression on the risk of developing frailty in older adults diagnosed with OSA.

Identification of Mycoviruses in : Potential Biocontrol Agents for Walnut Canker.

Walnut canker is a common disease in the Xinjiang Uygur autonomous region of China, which is caused by . To date, there is no effective control measure for this disease. Infection with mycoviruses has been widely proven to reduce the virulence of plant pathogenic fungi, with some mycoviruses even serving as potential biological control agents for plant diseases.

Recent advances and developments in solar-driven photothermal catalytic CO reduction into multicarbon (C) products.

Solar-driven catalytic conversion of carbon dioxide (CO) into value-added C chemicals and fuels has attracted significant attention over the past decades, propelled by urgent environmental and energy demands. However, the catalytic reduction of CO continues to face significant challenges due to inherently slow reduction kinetics. This review traces the historical development and current state of photothermal CO reduction, detailing the mechanisms by which CO is transformed into C products.

Selective Photocatalytic Oxidative Ethane Dehydrogenation on AuPd Nanoparticle-Decorated TiO.

Photocatalytic oxidative dehydrogenation of ethane offers a promising approach for producing ethylene under mild conditions. However, achieving high ethylene yields and selectivity is challenging due to the high C-H bond activation barrier in ethane and the tendency for overoxidation to CO. In this study, we demonstrate that TiO with highly dispersed AuPd nanoparticles serves as an efficient and selective photocatalyst for the dehydrogenation of ethane with O in a flow reactor.

First Report of Powdery Mildew Caused by on L. in Xinjiang, China.

Hibiscus trionum L., a member of the Malvaceae family and Hibiscus genus, is a prevalent weed in agricultural fields across Xinjiang, China. In September 2023, powdery mildew was observed on H.

Multimodal Splitting and Reciprocating Transport of Droplets on a Reprogrammable Functional Surface.

Droplet manipulations have important applications in many fields, especially droplet splitting and transport in aseptic operations or biochemical reagent analysis. However, droplet splitting or transport on existing functional surfaces is limited to predesigned microstructures or fixed patterns. It remains a challenge to realize reprogrammable surface microstructures for freely controllable droplet splitting and transport.

The optimised model of predicting protein-metal ion ligand binding residues.

Metal ions are significant ligands that bind to proteins and play crucial roles in cell metabolism, material transport, and signal transduction. Predicting the protein-metal ion ligand binding residues (PMILBRs) accurately is a challenging task in theoretical calculations. In this study, the authors employed fused amino acids and their derived information as feature parameters to predict PMILBRs using three classical machine learning algorithms, yielding favourable prediction results.

Development, implementation and evaluation of consultation case-based learning course to improve the interdisciplinary clinical reasoning ability-a pilot study from nephrology.

Background: In modern clinical settings, interdisciplinary clinical reasoning skills and associated education are pivotal and should be encouraged for residency training.

Methods: An interdisciplinary course on clinical reasoning was developed for residents based on ADDIE (Analysis, Design, Development, Implementation, and Evaluation) model. We collected frequently encountered consultation cases as our teaching resources with the methods of scenario case-based learning.

Pathway Elucidation and Key Enzymatic Processes in the Biodegradation of Difenoconazole by A-3.

The extensive agricultural use of the fungicide difenoconazole (DIF) and its associated toxicity increasingly damage ecosystems and human health. Thus, an urgent need is to develop environmentally friendly technological approaches capable of effectively removing DIF residues. In this study, strain A-3 was isolated for the first time which can degrade DIF efficiently.

Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision.

Introduction: Diabetic nephropathy (DN) is a common diabetes-related complication with unclear underlying pathological mechanisms. Although recent studies have linked glycolysis to various pathological states, its role in DN remains largely underexplored.

Methods: In this study, the expression patterns of glycolysis-related genes (GRGs) were first analyzed using the GSE30122, GSE30528, and GSE96804  datasets, followed by an evaluation of the immune landscape in DN.

Preparation of sulfur-doped porous carbon from polyphenylene sulfide waste for photothermal conversion materials to achieve solar-driven water evaporation.

In recent years, solar-driven photothermal water evaporation technology for seawater desalination and wastewater treatment has developed rapidly, which is of great significance for addressing the issue of freshwater scarcity. However, due to the high costs associated with the manufacturing, maintenance, and operation of such devices, their application remains challenging in remote and resource-scarce regions. Due to its excellent light absorption capability in the near-infrared region, high hydrophilicity, and stable chemical properties, coupled with the low cost of recycling waste carbonized polyphenylene sulfide, this material is an excellent choice as a photothermal material for solar-driven water evaporation devices.

The heart rate on admission was associated with the mortality in elderly patients with hip fractures: a retrospective cohort study from a trauma centre in northwestern China.

Objectives: To evaluate the association between heart rate on admission and mortality in elderly patients with hip fractures.

Design: A retrospective cohort study.

Setting: At a trauma centre in northwestern China.

Prospects for the development of medical professionalism education in the AI perspective: A qualitative study of Chinese postgraduate medical students' written reflections.

Introduction: Medical professionalism education is of paramount importance to the development of medical careers and medical students. Currently, there is a need for more research in China on the integration of artificial intelligence (AI) and medical professionalism education.

Methods: For this study, we collected 44 written reflections from first-year postgraduate students of clinical medicine in China during the spring semester of 2024 on the prospect of applying AI in conjunction with medical professionalism education.

Coordination Equilibrium-Assisted Coprecipitation Synthesis of Atomically Dispersed 3d Metal Catalysts.

As a frontier of heterogeneous catalysis, single-atom catalysts (SACs) have been extensively studied fundamentally. One obstacle that limits the industrial application of SACs is the lack of a synthetic method that can prepare the catalysts on a large scale. Wet-chemistry methods that are conventionally used to prepare nanoparticle-based industrial catalysts might be a solution.

Unraveling the degradation mechanism of multiple pyrethroid insecticides by Pseudomonas aeruginosa and its environmental bioremediation potential.

Extensive use of pyrethroid insecticides poses significant risks to both ecological ecosystems and human beings. Herein, Pseudomonas aeruginosa PAO1 exhibited exceptional degradation capabilities towards a range of pyrethroid family insecticides including etofenprox, bifenthrin, tetramethrin, D-cypermethrin, allethrin, and permethrin, with a degradation efficiency reaching over 84 % within 36 h (50 mg·L). Strain PAO1 demonstrated effective soil bioremediation by removing etofenprox across different concentrations (25-100 mg·kg), with a degradation efficiency over 77 % within 15 days.

Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity.

Background: Anterior tibial laxity is considered to be a risk factor for knee injuries, including anterior cruciate ligament ruptures. The anterior cruciate ligament reconstruction also aims to restore anterior tibial laxity. While anterior tibial laxity is considered to be linked to dynamic knee stability, the mechanisms connecting anterior tibial laxity to these stability issues are not fully understood.

U-Shaped Relationship Between MSpO Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study.

Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort.

Declining Influenza Vaccination Uptake, Attitudes, and Knowledge Among Healthcare Workers in Chengdu, China, in the Post-COVID-19 Era.

Purpose: Despite the benefits of influenza vaccination, particularly for healthcare workers (HCWs) at higher risk, vaccination coverage among HCWs in China remains low. This study aims to provide updated insights into the knowledge, attitudes, practices, and barriers related to influenza vaccination among HCWs in China post-COVID-19 era, to inform strategies for improving vaccination rates and healthcare safety.

Methods: A cross-sectional survey was conducted between December 2023 and January 2024 at two tertiary hospitals in Chengdu, China.

The mediating effect of psychosomatic symptoms between physical activity and cognitive function among breast cancer patients: A path analysis.

Purpose: Psychosomatic symptoms are frequently observed side effects in breast cancer (BC) patients and significantly influence cognitive function. However, limited research has addressed the role of psychosomatic symptoms in the relationship between physical activity and cognitive function. This study aimed to examine the mediating effect of psychosomatic symptoms on the relationship between physical activity and cognitive function in BC patients.

Inhibition of TOX exerts anti-tumor effects in acute myeloid leukemia by upregulating IRF7 expression.

Thymocyte selection-associated high mobility group box protein (TOX) is regarded as a crucial transcription factor involved in T cell exhaustion in acute myeloid leukemia (AML). Previous studies have identified aberrant TOX expression as a major oncogenic driver in hematologic malignancies, indicating that TOX may potentially be both an immune biomarker and an immunotherapy target. However, due to heterogeneity in the distribution patterns of TOX and its correlation with clinical prognosis, the mechanism underlying TOX-mediated tumor immune responses remains unclear.