Spatial and Single-Cell Transcriptomics Unraveled Spatial Evolution of Papillary Thyroid Cancer.

Recurrence and metastasis are the major issues for papillary thyroid cancer (PTC). Current morphological and molecular classification systems are not satisfied for PTC diagnosis due to lacking variant-specific morphological criteria and high signal-to-noise in mutation-based diagnosis, respectively. Importantly, intratumor heterogeneity is largely lost in current molecular classification system, which can be resolved by single cell RNA sequencing (scRNA-seq).

Potential Cryptic Diversity in the Genus (Carcharhiniformes: Carcharhinidae): Insights from Mitochondrial Genome Sequencing.

is a genus of small placental sharks living in offshore waters. For a long time, the genus was considered a monotypic genus until a valid species, , was confirmed in 2010. However, in the same study was not widely recognized because of the lack of evidence.

Gated spin manipulation in a bipolar Rashba semiconductor: a Janus TeSSe monolayer.

It is very important to realize the electronically controlled spin direction for spintronic devices. Inspired by the bipolar Rashba semiconductor (BRS) concept recently proposed by Yang's group (X. Fu, , 2023, (50), 11292-11297), which presented a novel solution for spin precession manipulation using a BRS, through first-principles calculations, we confirm that Janus TeSSe is a BRS.

Mapping pesticide residues in soil for China: Characteristics and risks.

The widespread application of pesticides in China has led to the accumulation of residues in soil. However, few regional studies have fully elucidated the characteristics of pesticide residues in soil (PRS) and the associated risks to the ecosystem and human health on a national level. Therefore, this study aims to compile a dataset on PRS in China from 2006 to 2020 and analyze the interactions and impacts between PRS and the environment.

Equibiaxial strain regulates the electronic structure and mechanical, piezoelectric, and thermal transport properties of the 2H-phase monolayers CrX (X = S, Se, Te).

A superior piezoelectric coefficient and diminutive lattice thermal conductivity are advantageous for the application of a two-dimensional semiconductor in piezoelectric and thermoelectric devices, whereas an imperfect piezoelectric coefficient and large lattice thermal conductivity limit the practical application of the material. In this study, we investigate how the equibiaxial strain regulates the electronic structure, and mechanical, piezoelectric, and thermal transport properties. Tensile strain can deduce the bandgap of the monolayer CrX (X = S, Se, Te), whereas compressive strain has an opposite effect.

Unveiling the importance of VOCs from pesticides applicated in main crops for elevating ozone concentrations in China.

Volatile organic compounds (VOCs) are considered as important precursors of ozone in the air, while the contribution of VOCs from pesticide application (PVOCs) to ozone production is unknown. Utilizing data from the Ministry of Agriculture and Rural Affairs of the People's Republic of China and ChinaCropPhen1km, this paper developed PVOC emission inventories with a resolution of 1 km for the main crops (rice, maize, and wheat) from 2012 to 2019 in China. The results revealed that pesticide application is an important VOC emission source in China.

Factors associated with heterochronic gastric cancer development post-endoscopic mucosal dissection in early gastric cancer patients.

Background: Endoscopic mucosal resection is an innovative method for treating early gastric cancer and has been widely used in clinical practice.

Aim: To analyze the factors associated with the development of heterochronic gastric cancer in patients with early gastric cancer who had undergone endoscopic mucosal dissection (EMD).

Methods: A cohort of patients with early gastric cancer treated using EMD was retrospectively analyzed, and patients who developed heterochronic gastric cancer after the surgery were compared with those who did not.

Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China.

Background: Preeclampsia (PE) mainly occurs in pregnant women and is hereditary. Several genome-wide association studies (GWAS) on Caucasian samples have reported some gene loci that are associated with preeclampsia. However, these studies have not reached consistent conclusions.

Hexagonal warping effect in the Janus group-VIA binary monolayers with large Rashba spin splitting and piezoelectricity.

In this paper, the electronic band structure, Rashba effect, hexagonal warping, and piezoelectricity of Janus group-VIA binary monolayers STe, SeTe, and SeTe are investigated based on density functional theory (DFT). Due to the inversion asymmetry and spin-orbit coupling (SOC), the STe, SeTe and SeTe monolayers exhibit large intrinsic Rashba spin splitting (RSS) at the point with the Rashba parameters 0.19 eV Å, 0.

Chronic high‑salt intake induces cardiomyocyte autophagic vacuolization during left ventricular maladaptive remodeling in spontaneously hypertensive rats.

The role of autophagy in high-salt (HS) intake associated hypertensive left ventricular (LV) remodeling remains unclear. The present study investigated the LV autophagic change and its association with the hypertensive LV remodeling induced by chronic HS intake in spontaneously hypertensive rats (SHR). Wistar Kyoto (WKY) rats and SHR were fed low-salt (LS; 0.

Air quality improvement through vehicle electrification in Hainan province, China.

To improve the ecological environment, provinces in China have set ambitious goals for the electrification of fossil-fuel-powered vehicles (FVs) and the promotion of electric vehicles (EVs). Hainan is the first province to propose a clean energy target that schedules the banning of new FVs sales from 2030. Therefore, Hainan is a good case study to illustrate how this policy might improve regional air quality over the coming years.

Assessment of volatile organic compound emissions from pesticides in China and their contribution to ozone formation potential.

Solvents, components of pesticide emulsifiable concentrates (ECs), emit quantities of volatile organic compounds (VOCs) into the atmosphere. In the air, their active involvement in oxidative chemical reactions with oxidants exposed to ultraviolet solar radiation can result in the formation of ozone. The quantitative assessment of VOC emissions from agricultural pesticide applications remains hampered by many factors, especially the volatility coefficient of solvents in pesticides.

Biaxial Tensile Strain-Induced Enhancement of Thermoelectric Efficiency of -Phase SeTe and SeTe Monolayers.

Thermoelectric (TE) materials can convert waste heat into electrical energy, which has attracted great interest in recent years. In this paper, the effect of biaxial-tensile strain on the electronic properties, lattice thermal conductivity, and thermoelectric performance of -phase SeTe and SeTe monolayers are calculated based on density-functional theory and the semiclassical Boltzmann theory. The calculated results show that the tensile strain reduces the bandgap because the bond length between atoms enlarges.

The coexistence of superior intrinsic piezoelectricity and thermoelectricity in two-dimensional Janus α-TeSSe.

Piezoelectric and thermoelectric materials that can directly convert mechanical and thermal energies into electricity have attracted great interest because of their practical applications in overcoming the challenges of the energy crisis. In this research, a new family of two-dimensional (2D) group-VI Janus ternary compounds with α and γ phases are predicted. After the stability testing, only the α-TeSSe monolayer has dynamic and thermal stability.

Pseudolaric Acid B Attenuates High Salt Intake-Induced Hypertensive Left Ventricular Remodeling by Modulating Monocyte/Macrophage Phenotypes.

BACKGROUND Studies in ApoE knockout mice have shown that pseudolaric acid B (PB) can act as an immunomodulatory drug and attenuate atherosclerosis progression by modulating monocyte/macrophage phenotypes. Our previous study demonstrated that high salt intake could shift the phenotype of monocytes/macrophages to an inflammatory phenotype, and that this shift was related to hypertension and hypertensive left ventricular (LV) remodeling. However, no comprehensive assessment of the effects of PB on hypertensive LV remodeling has been conducted.

Novel thermoelectric performance of 2D 1T- SeTe and SeTewith ultralow lattice thermal conductivity but high carrier mobility.

The design and search for efficient thermoelectric materials that can directly convert waste heat into electricity have been of great interest in recent years since they have practical applications in overcoming the challenges of global warming and the energy crisis. In this work, two new two-dimensional 1T-phase group-VI binary compounds SeTe and SeTewith outstanding thermoelectric performances are predicted using first-principles calculations combined with Boltzmann transport theory. The dynamic stability is confirmed based on phonon dispersion.

Effect and mechanism of prophylactic use of tadalafil during pregnancy on l-NAME-induced preeclampsia-like rats.

Introduction: Preeclampsia (PE) is a serious maternal inflammatory disease with endothelial cell dysfunction, and there is a lack of effective treatment and prevention. Tadalafil is considered to be a promising drug for PE. This study aimed to determine whether and how tadalafil use during early pregnancy alleviates PE induced by N-nitro-l-arginine-methyl-ester (l-NAME), an antagonist of nitric oxide synthase, in rats.

ELABELA improves endothelial cell function via the ELA-APJ axis by activating the PI3K/Akt signalling pathway in HUVECs and EA.hy926 cells.

Destruction of endothelial cells (ECs) function is involved in the structural and functional pathophysiological processes of preeclampsia (PE). Vascular endothelial injury may pre-exist for several years in women that develop PE and may pose increased risks for hypertension, coronary artery disease, and type-2 diabetes mellitus. Previous findings showed that Elabela (ELA), the endogenous ligand of the apelin (APJ) receptor expressed mainly on ECs, may play a protective role in early pregnancy and prevent PE.

Prognostic role of dysregulated circRNAs in patients with non-small cell lung cancer: a meta-analysis.

Background: Lung cancer is the leading cause of cancer incidence and mortality. Non-small cell lung cancer (NSCLC) accounts for the vast majority of lung cancer, which lacks comprehensive prognostic biomarkers to predict the prognosis of patients. This research was performed to assess the potential prognostic role of circular RNAs (circRNAs) in patients with NSCLC.

Complete mitochondrial genome and the phylogenetic position of the giant oarfish ().

The mitochondrial genome of was firstly elucidated and analyzed in this study. It had a double-stranded DNA molecule with the length of 16,536 bp and was made up 37 genes (13 protein-coding genes, 2 rRNA genes, and 22 tRNA genes) and one control region. Furthermore, the phylogenetic result demonstrated that clustered with and .

Triclosan-induced liver injury in zebrafish (Danio rerio) via regulating MAPK/p53 signaling pathway.

Long-term exposure of triclosan (TCS), an important antimicrobial agent, can lead to deleterious effects on liver growth and development. However, the related mechanisms on TCS-induced hepatocyte injury remain unclear. Herein, we found that after long-time TCS exposure to adult zebrafish (Danio rerio) from 6 hpf (hours post-fertilization) to 90 dpf (days post-fertilization), the body weight and hepatic weight were significantly increased in concomitant with a large amount of lipid droplet accumulation in liver.

Effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension.

Evidence has shown that angiotensin II type 1 receptor antagonists have lower blood pressure and have target organ protective effects, but this is not the case for the drug allisartan isoproxil. The aim of this study was to evaluate the effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension.In total, 80 essential hypertensive participants were randomly divided into an allisartan group and a nifedipine group (n = 40 per group), and their blood pressure was measured once per month for 6 months.

Chuzan Virus in Yaks, Qinghai-Tibetan Plateau, China.

We detected Chuzan virus (CHUV) in domestic yaks from the Qinghai-Tibetan Plateau, western China, indicating CHUV probably has been transmitted to yaks in recent years. Awareness for CHUV surveillance and transmission and livestock health management in these special regions should be raised to avoid outbreaks and animal loss.

Predictive Factors of Lateral Lymph Node Metastasis in Papillary Thyroid Microcarcinoma.

This study was designed to determine the incidence and predictive factors for lateral lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). From January 2014 to July 2015, a retrospective review was conducted of 215 patients with PTMC who underwent total thyroidectomy and central lymph node dissection (LND) with lateral LND. Correlations of lateral LNM with clinicopathological features were examined using univariate analyses.