[Influence of seven absorption enhancers on nasal mucosa--assessment of toxicity].

Objective: To study the influence of seven different absorption enhancers on nasal mucosa.

Methods: By testing last time of ciliary movement, velocity of ciliary movement, ciliary structural and specific cellular changes of nasal mucosa the influence of seven different absorption enhancers on nasal mucosa.

Results: The effect on lasting time of ciliary movement was 1%SDS>1%SDC>1%Brij35>5%Tween80>0.

[Preparation and properties of 5-fluorouracil-loaded chitosan microspheres for the intranasal administration].

Objective: To study the preparation technique and release characteristic of 5-fluorouracil loaded chitosan microspheres for the intranasal administration.

Methods: Using the liquid paraffin as the oil phase,and span-80 as the emuifier; 5-fluorouracil-loaded chitosan microspheres were achieved by emulsion-chemical crosslink technique. The orthogonal experimental design was applied to optimize the preparation procedure.