Sex-specific gene expression patterns in head and neck squamous cell carcinomas.

Objective: The head and neck squamous cell carcinomas (HNSCCs) have higher incidence rates in men, but the reasons are still obscure. This study aimed to investigate the sex-specific gene expression patterns and predict the regulatory mechanisms.

Design: Data including clinical, survival, RNA-seq, miRNA, and methylation information were derived from The Cancer Genome Atlas (TCGA).

Diagnostic Value of Circulating PIGF in Combination with Flt-1 in Early Cervical Cancer.

The utility of placental growth factor (PlGF) and its receptor VEGFR-1 (Flt-1) as biomarkers for cervical cancer has not been clarified yet. To address this issue, we investigated the levels of soluble PlGF (sPlGF) and soluble Flt-1 (sFlt-1) in the serum from patients with early cervical cancer, cervical intraepithelial neoplasia (CIN) and controls in this study. sPlGF and sFlt-1 were detected in 44 preoperative patients with cervical cancer, 18 cases with CIN, and 20 controls by ELISA.

[The role and mechanism of CXCR4 and its ligand SDF-1 in the development of cervical cancer metastasis].

Background & Objective: The chemokine receptor CXCR4 and its sole ligand stromal cell-derived factor-1 (SDF-1) not only actively participate in inflammation, hematopoiesis, infection of HIV, but also play a pivotal role in migration, invasion and metastasis of some malignant tumors. This study was to investigate the role of CXCR4/SDF-1 axis in mediating metastasis in cervical cancer cells through activating the mitogen-activated protein kinase (MAPK) pathway and its possible mechanism.

Methods: Intracellular calcium mobilization was observed under laser scanning confocal fluorescence microscopy.

Impact of menopause on quality of life in community-based women in China.

Objective: To assess the impact of menopause, age, and other factors on quality of life (QOL).

Design: Generally healthy women aged 35 to 64 years were recruited from a general community in Beijing, People's Republic of China. An instrument including the Chinese version of the Menopause-Specific Quality of Life Questionnaire was used to obtain data.

[Profiles of irregular bleeding induced by low-dose hormone therapy and Chinese formulated herbs products].

Objective: To compare profiles and related factors of irregular bleeding induced by different types of low-dose hormone therapy (HT) and a Chinese formulated herbs products.

Methods: Applied with open-labeled, randomized, and clinical trial design, 136 postmenopausal women were assigned into four groups: group A: estradiol valerate (E2 V) 1 mg/d + medroxyprogesterone acetate (MPA) 2 mg/d; group B: conjugated equine estrogen 0.45 mg/d + MPA 2 mg/d; group C: tibolone 1.

[Reliability of an improved measurement system used in three-dimensional reconstruction of stomatognathic system by cutting and scanning layer-by-layer].

Objective: To reconstruct 3D shape of edentulous jaw by using improved measurement system and to analyze the precision of this method.

Methods: Standard edentulous jaw models were measured with a improved measurement system by cutting and scanning layer-by-layer, and the 3D shape of the models was reconstructed by image processing with specialty software. Ten cubic plaster modes were reconstructed by the same way, data of every border before and after reconstruction were measured and analyzed.

[The bond properties of Vitadur alpha on dental zirconia framework material].

Purpose: To evaluate the bond properties of Vitadur alpha on dental zirconia framework material.

Methods: Vitadur alpha was sintered on the surface of four groups' presintered zirconia ceramic plates which were dealt with respective procedures. SEM, energy distribution spectrum and thermal shock test were applied to evaluate the sintering properties of such interfaces.