Wireless Multimodality Sensing System-on-a-Chip With Time-Based Resolution Scaling Technique and Analog Waveform Generator in 0.18 μm CMOS for Chronic Wound Care.

Multimodal sensing can provide a comprehensive and accurate diagnosis of biological information. This paper presents a fully integrated wireless multimodal sensing chip with voltammetric electrochemical sensing at a scanning rate range of 0.08-400 V/s, temperature monitoring, and bi-phasic electrical stimulation for wound healing progress monitoring.

A 19 μW, 50 kS/s, 0.008-400 V/s Cyclic Voltammetry Readout Interface With a Current Feedback Loop and On-Chip Pattern Generation.

A cyclic voltammetry electrochemical sensing chip was implemented with a time-based readout circuit and a current feedback control loop for wide-range and high-linearity current detection. The design utilizes a chopper-stabilized, low-noise potentiostat circuit and a delay chain time-to-digital converter to improve accuracy and the conversion rate. A current feedback loop is employed to mitigate nonlinearity of the current-to-frequency converter.

A Two-Electrode, Double-Pulsed Sensor Readout Circuit for Cardiac Troponin I Measurement.

This paper presents a pulse-stimulus sensor readout circuit for use in cardiovascular disease examinations. The sensor is based on a gold nanoparticle plate with an antibody post-modification. The proposed system utilizes gated pulses to detect the biomarker Cardiac Troponin I in an ionic solution.

A Reconfigurable, Pulse-shaping Potentiometric Readout System for Bio-Sensing Transistors.

This paper presents a new multi-modality readout system for potentiometric electrochemical sensors. The design adopts a pulse modulation at the gate and drain of the Bio-FET sensors to reduce the effects of charge accumulation between the surface of the electrodes and the ion analytes. The adjustable duration and amplitude of stimuli signals provide flexibility for different biosensing applications and a wide range of detectable concentration.

Design and Study of a Portable High-frequency Ventilator for Clinical Applications.

Treatment costs for ventilator-dependent patients are a substantial burden not only for their family but also for medical systems in general. Recently, using high-frequency ventilators have been shown to reduce the risk of lung injury through low-volume airflow. However, the machines used today remain bulky, costly, and only for use in hospital settings.

A Microwatt Dual-Mode Electrochemical Sensing Current Readout With Current-Reducer Ramp Waveform Generation.

An electrochemical sensing chip with an integrated current-reducer pattern generator and a current-mirror based low-noise chopper-stabilization potentiostat circuit is presented. The pattern generator, utilizing the current reducer technique and pseudo resistors, creates a sub-Hz ramp signal for the cyclic voltammetric (CV) measurement without large-size passive components. The proposed design adopts the chopper-stabilization and low-noise biasing technique for the potentiostat and a counter-based time-to-digital converter to reduce the amplitude noise effects and to convert the sensing current signal to digital codes for further data processing.