Identification of UDP-glucuronosyltransferase (UGT) isoforms involved in the metabolism of Chlorophenols (CPs).

Chlorophenols (CPs) are a group of pollutants that pose a great threat to the environment, they are widely used in industrial and agricultural wastes, pesticides, herbicides, textiles, pharmaceuticals and plastics. Among CPs, pentachlorophenol was listed as one of the persistent organic pollutants (POPs) by the Stockholm convention. This study aims to identify the UDP-glucosyltransferase (UGT) isoforms involved in the metabolic elimination of CPs.

Effect modification by aging on the associations of nicotine exposure with cognitive impairment among Chinese elderly.

Active and passive exposure to tobacco smoke may increase risk of cognitive decline. However, effects of enhanced the aging process on the association of urinary nicotine metabolites with cognitive impairment remain unclear. In this study, 6657 Chinese older adults completed the physical examinations and cognitive tests.

Non-linear dose-response relation between urinary levels of nicotine and its metabolites and cognitive impairment among an elderly population in China.

Background: Active smoking and exposure to environmental tobacco smoke may be related to cognitive function decline. We assessed the associations of urinary levels of nicotine and its metabolites with cognitive function.

Methods: A total of 553 elder adults at high risk of cognitive impairment and 2212 gender- and age-matched individuals at low risk of cognitive impairment were selected at a ratio of 1: 4 from the remained individuals (n = 6771) who completed the baseline survey of the Shenzhen Ageing-Related Disorder Cohort, after excluding those with either Alzheimer's disease, Parkinson's syndrome or stroke as well as those with missing data on variables (including active and passive smoking status, Mini-Cog score).

Phthalate exposure linked to high blood pressure in Chinese children.

Background: Exposure to phthalate esters may be linked to the risk of high blood pressure (HBP), but limited evidence is available in Chinese children.

Objective: To investigate the associations between nine phthalate metabolites (mPAEs) and systolic/diastolic BP, pulse pressure (PP), mean arterial pressure (MAP), and the risk of HBP.

Methods: In this cross-sectional study, a total of 1044 primary school children (6-8 years old) were enrolled from Shenzhen, China, between 2016 and 2017.

[Pollution Characteristics and Evaluation of Heavy Metal Pollution in Surface Soil Around a Municipal Solid Waste Incineration Power Plant].

To investigate and evaluate the pollution levels of heavy metals in the soil around a large Municipal Solid Waste Incineration power plant (MSWIPP), a total of 29 soil samples were collected around the MSWIPP and away from the power plant area. The contents of 10 selected heavy metals (Cr, Mn, Ni, Cu, Zn, As, Ag, Cd, Hg, and Pb) were analyzed. The results showed that the content of each heavy metal element did not exceed the values for Soil Environmental Quality of Risk Control Standard for Soil Contamination of Agricultural Land (GB15618-2018) and Development Land (GB 36600-2018).

A pilot study of metabolites of organophosphorus flame retardants in paired maternal urine and amniotic fluid samples: potential exposure risks of tributyl phosphate to pregnant women.

Organophosphorus flame retardants (OPs) are of wide concern due to their presence in human urine and their considerable endocrine disruption and neuro-development toxicity. It has been confirmed that electronic waste (e-waste) dismantling activities have contributed to human exposure to OPs. However, assessments of OP exposure and the health risks for pregnant women and fetuses living in areas associated with e-waste dismantling have been impeded by a lack of data.

Urinary metabolites of organophosphate flame retardants in China: Health risk from tris(2-chloroethyl) phosphate (TCEP) exposure.

Organophosphate esters (OPs) are substitutes for polybrominated diphenyl ether (PBDE) flame retardants. China is the largest producer of OPs globally, with the production rate increasing at 15% annually. Since some OPs are neurodevelopmental and/or carcinogenic toxicants, human exposure is a concern.

Effect of E-waste Recycling on Urinary Metabolites of Organophosphate Flame Retardants and Plasticizers and Their Association with Oxidative Stress.

In this study, three chlorinated (Cl-mOPs) and five nonchlorinated (NCl-mOPs) organophosphate metabolites were determined in urine samples collected from participants living in an electronic waste (e-waste) dismantling area (n = 175) and two reference areas (rural, n = 29 and urban, n = 17) in southern China. Bis(2-chloroethyl) phosphate [BCEP, geometric mean (GM): 0.72 ng/mL] was the most abundant Cl-mOP, and diphenyl phosphate (DPHP, 0.

Associations between polycyclic aromatic hydrocarbon (PAH) exposure and oxidative stress in people living near e-waste recycling facilities in China.

Emission of polycyclic aromatic hydrocarbons (PAHs) from e-waste recycling activities in China is known. However, little is known on the association between PAH exposure and oxidative damage to DNA and lipid content in people living near e-waste dismantling sites. In this study, ten hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and two biomarkers [8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA)] of oxidative stress were investigated in urine samples collected from people living in and around e-waste dismantling facilities, and in reference population from rural and urban areas in China.

Brominated flame retardant emissions from the open burning of five plastic wastes and implications for environmental exposure in China.

Based on the most widely used plastics in China, five plastic wastes were selected for investigation of brominated flame retardant (BFR) emission behaviors during open burning. Considerable variations were observed in the emission factors (EF) of polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) from the combustion of different plastic wastes. Distribution of BFR output mass showed that ΣPBDE was emitted mainly by the airborne particle (51%), followed by residual ash (44%) and the gas phase (5.

Toxaphene levels in retail food from the Pearl River Delta area of South China and an assessment of dietary intake.

Limited literature exists on toxaphene contamination in food worldwide, particularly in mainland China. In this study, three toxaphene congeners, Parlar 26 (B8-1413), Parlar 50 (B9-1679) and Parlar 62 (B9-1025), were analyzed in five different food categories from the Pearl River Delta Area in China using isotope dilution high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS), and toxaphene levels in food were reported and toxaphene dietary intake by local residents estimated. The results showed that fish contained the highest toxaphene level with a median of 12.

Trace elements contamination and human health risk assessment in drinking water from Shenzhen, China.

The levels of seven essential trace elements (Mn, Co, Ni, Cu, Zn, Se, and Mo) and six non-essential trace elements (Cr, As, Cd, Sb, Hg, and Pb) in a total of 89 drinking water samples collected in Shenzhen, China were determined using inductively coupled plasma mass spectrometry (ICP-MS) in the present study. Both the essential and non-essential trace elements were frequently detectable in the different kinds of drinking waters assessed. Remarkable temporal and spatial variations were observed among most of the trace elements in the tap water collected from two tap water treatment plants.

Bisphenol A in supermarket receipts and its exposure to human in Shenzhen, China.

Paper receipt has been documented as one major source of bisphenol A (BPA) for human exposure but little has been done by researchers to elaborate the potential health risk caused by handling paper receipt up to date. In the present study, BPA was analyzed in 42 supermarket receipts collected from Shenzhen, China. BPA was detected in all samples at concentrations ranging from 2.

Food as a main route of adult exposure to PBDEs in Shenzhen, China.

The present study measured eight PBDE congeners' (BDE-28, 47, 99, 100, 153, 154, 183, and 209) exposure via ingestion of indoor dust and soil, inhalation, and food consumption. Contributions to PBDEs exposure from different media revealed that indoor dust (dust suspended in air) was not an important exposure route for PBDE congeners for adults in Shenzhen, China. Food consumption contributed more to daily intake of Σ(8)BDE, especially for lower-brominated PBDE congeners.

Increased urinary 8-hydroxy-2'-deoxyguanosine levels in workers exposed to di-(2-ethylhexyl) phthalate in a waste plastic recycling site in China.

Background: Di-(2-ethylhexyl) phthalate (DEHP) is a common plasticizer used in industrial and diverse consumer products. Animal studies indicate DEHP caused developmental, reproductive, and hepatic toxicities. However, human studies of the potential effects of DEHP are limited.