Publications by authors named "Shao-Ting Li"
Atopic dermatitis is featured with impaired skin barrier. The stratum corneum and the intercellular tight junctions constitute the permeability barrier, which is essential to protect water loss in the host and prevent pathogen entry. The epidermal barrier is constantly renewed by differentiating keratinocytes through cornification, during which autophagy contributes to elimination of organelles and nucleus.
View Article and Find Full Text PDFArticle Synopsis
- Hair follicles go through cycles of growth, rest, and regression supported by stem cells, and certain mutations can disrupt these processes, leading to hair loss and skin inflammation.
- An overexpression of the Gsdma3 gene in mice causes significant disruptions in hair cycling, including cell death during key stages that leads to hair follicle degeneration.
- The study reveals that while immune cells are present in the affected areas, they do not seem to directly cause hair follicle damage, suggesting that Gsdma3 plays a critical role in maintaining the hair follicle stem cell environment.
Adult hair follicles undergo repeated cycling of regression (catagen), resting (telogen), and growth (anagen), which is maintained by hair follicle stem cells (HFSCs). The mechanism underlying hair growth initiation and HFSC maintenance is not fully understood. Here, by epithelial deletion of Hes1, a major Notch downstream transcriptional repressor, we found that hair growth is retarded, but the hair cycle progresses normally.
View Article and Find Full Text PDF