Publications by authors named "Shao-Tao Pan"
Article Synopsis
- Single-factor interventions like exercise and sensory stimulation can help with Alzheimer’s disease (AD), but their effects are limited and not well-understood, prompting a study on multifactor interventions.
- The study investigated the combined effects of voluntary exercise and acoustic-visual stimulation on neurogenesis and behavior in a mouse model of AD, finding significant improvements in new cell production and cognitive function after 4 weeks.
- Results showed that multifactor interventions led to a higher differentiation of new cells into neurons and astrocytes, improved cognitive abilities, reduced anxiety and depression-like behaviors, altered protein levels linked to brain health, and positively impacted metabolites related to neuronal function.
Physical exercise plays a role on the prevention and treatment of Alzheimer's disease (AD), but the exercise mode and the mechanism for these positive effects is still ambiguous. Here, we investigated the effect of an aerobic interval exercise, running in combination with swimming, on behavioral dysfunction and associated adult neurogenesis in a mouse model of AD. We demonstrate that 4 weeks of the exercise could ameliorate Aβ oligomer-induced cognitive impairment in mice utilizing Morris water maze tests.
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