Discovery of thirteen cobalt(II) and copper(II) salicylaldehyde Schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549/DDP cells and that can overcome cisplatin resistance and .

In this study, 13 transition metal complexes, namely, [Cu(LH)(HO)]·(HO)·NO (1), [Cu(LH)]·(NO)·(HO) (2, = 2; 3, = 3; 4, = 4; 5, = 5), [Co(LH)]·(HO) (6, = 2; 7, = 3; 8, = 4; 9, = 5), [Cu(LH)(LH)(phen)]·(CHOH) (10), [Cu(LH) (phen)]·(HO) (11), [Cu(LH)(LH)(phen)]·(HO)(CHOH) (12), and [Cu(LH) (phen)]·(HO)·(CHOH) (13), were synthesized using Schiff base ligands and characterized by elemental analysis (EA), infrared spectroscopy (IR), and single-crystal X-ray diffraction (SC-XRD). Compared with complexes 1-9, complexes 10-13 displayed stronger cytotoxic activities against the tested A549/DDP cancer cells (IC = 0.97-3.

Solvent and Copper Ion-Induced Synthesis of Pyridyl-Pyrazole-3-One Derivatives: Crystal Structure, Cytotoxicity.

Five novel compounds, methyl 5-(acetyloxy)-1-(6-bromo-2-pyridinyl)-1-pyrazole-3-carboxylate (), methyl 1-(6-bromo-2-pyridinyl)-5-hydroxy-1H-pyrazole-3-carboxylate (), Trimethyl 1,1',1''-tris(6-bromo-2-pyridinyl)-5,5''-dihydroxy-5'-oxo-1',5'-dihydro-1H,1''H-4,4': 4',4''-terpyrazole-3,3',3''-tricarboxylate (H₂L¹, ), [Cu₂(L²)₂]·CH₃OH (), H₂L·CH₃CN () were synthesized. Compounds - characterized by elemental analysis, IR, and X-ray single-crystal diffraction. And - were also characterized by ¹H NMR, C NMR and ESI-MS.

[Synergism inhibition of curcumin combined with cisplatin on T24 bladder carcinoma cells and its related mechanism].

Objective: To investigate the synergism inhibition of curcumin combined with cisplatin on T24 bladder carcinoma cells and the down-regulating effect of curcumin on the Keapl-Nrf2 pathway, a well recognized anti-drug pathway in almost drugged tumor cells.

Methods: T24 cells were cultured and treated with increasing concentrations of curcumin(5 ,10 and 20 µmol/mL) combined with cisplatin(30 µg/mL) for 24 hours. The inhibitory effects on T24 cells were tested with MTI colorimetric assay.