Publications by authors named "Shao-Lun Chiou"
A Boron-Dependent Antibiotic Derived from a Calcium-Dependent Antibiotic.
Angew Chem Int Ed Engl
January 2024
Article Synopsis
- The rise of drug-resistant bacteria poses a significant threat to healthcare, highlighting the need for new antibiotics.
- Calcium-dependent antibiotics (CDAs) like laspartomycin C (LspC) show promise against infections, but their reliance on calcium limits their effectiveness.
- Researchers developed a synthetic LspC analogue called B1, which uses phenylboronic acid instead of calcium, maintaining antibacterial activity against resistant strains while paving the way for innovative antibiotic design.
The traditional natural product discovery approach has accessed only a fraction of the chemical diversity in nature. The use of bioinformatic tools to interpret the instructions encoded in microbial biosynthetic genes has the potential to circumvent the existing methodological bottlenecks and greatly expand the scope of discovery. Structural prediction algorithms for nonribosomal peptides (NRPs), the largest family of microbial natural products, lie at the heart of this new approach.
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