Publications by authors named "Shao-Long Mao"
There is increasing evidence that deep sequencing-based T cell repertoire can sever as a biomarker of immune response in cancer patients; however, the characteristics of T cell repertoire including diversity and similarity, as well as its prognostic significance in patients with cervical cancer (CC) remain unknown. In this study, we applied a high throughput T cell receptor (TCR) sequencing method to characterize the T cell repertoires of peripheral blood samples from 25 CC patients, 30 cervical intraepithelial neoplasia (CIN) patients and 20 healthy women for understanding the immune alterations during the cervix carcinogenesis. In addition, we also explored the signatures of TCR repertoires in the cervical tumor tissues and paired sentinel lymph nodes from 16 CC patients and their potential value in predicting the prognosis of patients.
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- SAMHD1 is a key protein that helps prevent HIV-1 infection in myeloid cells, but its function can be hindered by the viral protein Vpx.
- Research on the genetic variations (polymorphisms) of SAMHD1 in different macaque species revealed two specific variants (T168C and T320C) that affect viral load, particularly in rhesus macaques.
- The study concluded that while SAMHD1 polymorphisms didn't impact SIVmac239 replication in cynomolgus macaques, they potentially influence HIV-2ROD infection in rhesus macaques, highlighting the complex interactions between viral types and host genetics.