MNC-Net: Multi-task graph structure learning based on node clustering for early Parkinson's disease diagnosis.

Purpose: The identification of early-stage Parkinson's disease (PD) is important for the effective management of patients, affecting their treatment and prognosis. Recently, structural brain networks (SBNs) have been used to diagnose PD. However, how to mine abnormal patterns from high-dimensional SBNs has been a challenge due to the complex topology of the brain.

Pre-anesthetic clinic internship: new teaching method of pre-anesthesia evaluation for undergraduates.

Background: This study aimed to observe the effect of internship in a pre-anesthetic clinic on the teaching quality of pre-anesthesia evaluation for undergraduates.

Methods: A total of 120 undergraduates from July 2017 to July 2018 in the anesthesia department of our hospital were randomly divided into two groups: pre-anesthetic clinic internship teaching group (n = 60) and traditional teaching group (n = 60). The knowledge in the pre-anesthesia evaluation teaching chapters was evaluated between the two groups of undergraduates.

Neural Remodeling of the Left Atrium in Rats by Rosuvastatin Following Acute Myocardial Infarction.

Objective: This study aims to investigate the effect of rosuvastatin on sympathetic neural remodeling of the left atrium (LA) in rats after myocardial infarction (MI).

Methods: Rats were randomly divided into a three groups: sham group, statin group, and MI group. The mRNA expression levels of the growth-associated protein-43 (GAP43) and nerve growth factor (NGF) were measured by RT-PCR.

Penehyclidine hydrochloride suppressed peripheral nerve injury-induced neuropathic pain by inhibiting microglial MAPK/p-p38/IL-1 pathway activation.

Background: Millions of people suffered from neuropathic pain, which is related to neuroinflammation in the central nervous system. Penehyclidine hydrochloride is a premedication of general anesthesia, which has been confirmed possessing neuroprotective effects against various neurodegenerative or neuroinflammatory diseases. However, it is not clear that whether penehyclidine hydrochloride could suppress neuropathic pain through its anti-neuroinflammatory effects.