Establishment and Verification of an Artificial Intelligence Prediction Model for Children With Sepsis.

Background: Early identification of high-risk groups of children with sepsis is beneficial to reduce sepsis mortality. This article used artificial intelligence (AI) technology to predict the risk of death effectively and quickly in children with sepsis in the pediatric intensive care unit (PICU).

Study Design: This retrospective observational study was conducted in the PICUs of the First Affiliated Hospital of Sun Yat-sen University from December 2016 to June 2019 and Shenzhen Children's Hospital from January 2019 to July 2020.

Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway.

Enhancer of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), is a histone lysine methyltransferase mediating trimethylation of histone H3 at lysine 27 (H3K27me3), which is a repressive marker at the transcriptional level. EZH2 sustains normal renal function and its overexpression has bad properties. Inhibition of EZH2 overexpression exerts protective effect against acute kidney injury (AKI).

Enterovirus D68 in hospitalized children with respiratory symptoms in Guangdong from 2014 to 2018: Molecular epidemiology and clinical characteristics.

Background: Enterovirus D68 (EV-D68) is an emerging pathogen in humans. EV-D68 causes a wide range of respiratory symptoms in children and has the propensity to cause severe complications. EV-D68 outbreaks are rarely investigated in mainland China.

Continuous Renal-Replacement Therapy in Critically Ill Children: Practice Changes and Association With Outcome.

Objectives: This study was designed to evaluate practice changes and outcomes over a 10-year period in a large single-center PICU cohort that received continuous renal-replacement therapy.

Design: Retrospective study design.

Setting: A multidisciplinary tertiary PICU of a university-affiliated hospital in Guangzhou, China.

Changes in enterovirus serotype constituent ratios altered the clinical features of infected children in Guangdong Province, China, from 2010 to 2013.

Background: Enterovirus (EV)-related hand, foot, and mouth disease/herpangina (HFMD/HA) has been prevalent in Guangdong Province, China, since 2010.

Methods: Clinical data for EV-related HFMD/HA inpatients admitted to the Department of Paediatrics of Zhujiang Hospital from 2010 to 2013 were retrospectively reviewed. The corresponding EV serotypes were also determined by reverse transcription-polymerase chain reaction or BLAST analysis of the sequenced partial lengths of the viral protein1/5'-untranslated region.

Enterovirus-related diarrhoea in Guangdong, China: clinical features and implications in hand, foot and mouth disease and herpangina.

Background: A series of complications caused by enteroviruses, including meningitis, encephalitis, acute flaccid paralysis, acute cardiopulmonary failure, respiratory infection, and myocardial injury have been reported in hand, foot and mouth disease/herpangina (HFMD/HA). However, the complication of diarrhoea caused by enteroviruses has been neglected, and a summary of its clinical features and impact on HFMD/HA is unavailable.

Methods: We included inpatients with HFMD/HA admitted to the Paediatric Department of Zhujiang Hospital during 2009-2012.

[Gas Concentration Measurement Based on the Integral Value of Absorptance Spectrum].

The absorptance spectrum of a gas is the basis for the qualitative and quantitative analysis of the gas by the law of the Lambert-Beer. The integral value of the absorptance spectrum is an important parameter to describe the characteristics of the gas absorption. Based on the measured absorptance spectrum of a gas, we collected the required data from the database of HIT-RAN, and chose one of the spectral lines and calculated the integral value of the absorptance spectrum in the frequency domain, and then substituted the integral value into Lambert-Beer's law to obtain the concentration of the detected gas.

Elevated levels of cerebrospinal fluid S100B are associated with brain injury and unfavorable outcomes in children with central nervous system infections.

Purpose: This work aimed to assess whether elevated levels of cerebrospinal fluid (CSF) S100B are associated with brain injury and unfavorable outcomes at discharge in children with central nervous system (CNS) infections.

Methods: CSF S100B and associated clinical parameters were retrospectively analyzed in 83 children with CNS infections and 88 children without neurological pathology served as controls. Children with CNS infections were divided into an infectious encephalitis group and an infectious meningitis group based on whether cerebral parenchyma was involved, and CSF S100B levels in different age subgroups between the two groups were compared.

[A preliminary study of long-term mitochondrial dysfunction in rat brain caused by lipopolysaccharide-induced sepsis].

Objective: To preliminarily investigate the long-term structural and functional injuries of mitochondria in rat brain caused by sepsis.

Methods: Wistar rats were randomly assigned into sepsis and control groups. A rat model of sepsis was prepared by an intraperitoneal injection of 10 mg/kg lipopolysaccharide (LPS) of gram-negative bacteria, and the survival assay was performed.

[A Detection Technique for Gas Concentration Based on the Spectral Line Shape Function].

The methods that can rapidly and precisely measure concentrations of various gases have extensive applications in the fields such as air quality analysis, environmental pollution detection, and so on. The gas detection method based on the tunable laser absorption spectroscopy is considered a promising technique. For the infrared spectrum detection techniques, the line shape function of an absorption spectrum of a gas is an important parameter in qualitative and quantitative analysis of a gas.

The absence of exanthema is related with death and illness severity in acute enterovirus infection.

Objective: To clarify whether exanthema is related to illness severity in acute enterovirus infection in children.

Methods: The data of pediatric inpatients at Zhujiang Hospital during 2009-2012 with an acute enterovirus infection were reviewed retrospectively. Enterovirus infection was determined by real-time reverse transcription PCR.

[Accurate calculation of spectral line profiles by considering influence of varying pressure and temperature in a gas].

Accurate calculation of spectral line profiles of a gas is very important for gas sensing. As we know, a variation in pressure (temperature) of a gas will result in the corresponding variation in temperature (pressure) of the gas. In the present paper we calculated spectral line profiles of a gas by considering the changes in both temperature and pressure.

Particle sizing of colloidal suspensions by low-coherence fiber optic dynamic light scattering.

A low-coherence fiber optic dynamic light scattering technique is used to measure the particle size distributions of colloidal suspensions with different volume fractions. We detect electric field autocorrelation function of the singly backscattered light from a sample and use the CONTIN algorithm to obtain the particle size distributions. As a result, in the range of volume fractions from 0.

Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans.

Background: An epidemic of urinary stones affecting children after consumption of melamine tainted milk is unfolding. We defined clinicopathological features of the disease for diagnosis, monitoring, and treatment of this group of patients.

Methods: A clinicopathological study on exposed children with ultrasonographic evidence of urolithiasis was conducted.

[Detection of angiotensin II in the maternal-fetal interface in pregnancy-induced hypertension].

Objective: To detect angiotensin II (ANG II) in the maternal blood, umbilical cord blood, and at the maternal-fetal interface in women with pregnancy-induced hypertension (PIH) and explore the etiology of PIH and pathophysiologic mechanism of intrauterine growth restriction (IUGR).

Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration of ANG II in the maternal blood, cord blood, and maternal and fetal placental tissues in 30 women with PIH and 30 with normal pregnancy, and the results were analyzed with independent-sample t test and Pearson correlation analysis.

Results: ANG II level in the maternal placental tissue homogenate showed no significant difference between women with PIH and normal pregnant women (8.

[Incidence and risk factor analysis of neonatal apnea in the representative regions of Guangdong Province].

Objective: To conduct an epidemiological survey of the prevalence of neonatal apnoea and and identify its risk factors in Guangdong Province.

Methods: The epidemiological data of neonatal apnea were collected by means of cluster sampling from 10 representative regions of Guangdong Province, and the risk factors for this condition were analyzed with logistic regression.

Results: In the representative regions chosen for this survey, the incidence of neonatal apnea was 9.

[Continuous blood purification in the treatment of pediatric septic shock].

Objective: To investigate the efficacy of continuous blood purification (CBP) and to explore its mechanism in the treatment of pediatric septic shock.

Methods: Nine children weighted 3.1 kg - 14.

Self-reconstruction property of fractional Bessel beams.

We study the self-reconstruction property of a fractional Bessel beam (FBB), where the FBB is described in terms of a Bessel beam of a fractional order for both amplitude and azimuthal phase components. The simulation and experimental results show that the FBB can overcome a block of obstacles and regenerate itself after a characteristic distance. As a comparison, the propagation of a Gaussian beam and an integer-order Bessel beam (IBB) through the same obstacles are also studied.

[Expression of telomerase reverse transcriptase and its significance in human fetal lung development].

Objective: To investigate the expression and distribution of telomerase reverse transcriptase (hTERT) and its significance during the development of epithelial stem cells in human fatal lungs.

Methods: Human lung tissues were obtained at abortion from 37 fetuses 10-34 weeks of gestational age with parental consent, and the expression of hTERT in these tissues was examined by immunohistochemistry.

Results: In fetuses of 10 weeks old, hTERT was detected mainly in the epithelial cells of the proximal bronchi in the fetal lung, and migrated gradually to the distal bronchi as the lung developed.

Practical implementation of the phase-quantization technique in an iterative Fourier-transform algorithm.

Implementation of the phase-quantization method in the design of computer-generated holograms (CGHs), especially binary CGHs, is a major influence on the diffraction efficiency of the CGHs. We describe the use of various quantization methods in the various steps of an iterative Fourier-transform algorithm and compare the root-mean-square (RMS) errors of the CGHs. As a result of the practical quantization technique, the most effective RMS value of a binary CGH should be decreased by at least 13% to retain maximum diffraction efficiency.

Experimental study of holographic generation of fractional Bessel beams.

We demonstrate the experimental generation of a fractional Bessel beam by holographic means. Such fractional modes of Bessel beams possess an intrinsic opening gap across concentric intensity rings on propagation. We also show that the opening gaps within the fractional modes are diffraction free for a working distance while a fractional helical wave front is maintained.