SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models.

Emerging evidence demonstrates that a c-Met antibody-drug conjugate (ADC) has superior efficacy and safety profiles compared with those of currently available small molecules or antibody inhibitors for the treatment of c-Met-overexpressing cancers. Here we described both the in vitro and in vivo efficacies of SHR-A1403, a novel c-Met ADC composed of a humanized IgG2 monoclonal antibody against c-Met conjugated to a novel cytotoxic microtubule inhibitor. SHR-A1403 showed high affinity to c-Met proteins derived from human or monkey and potent inhibitory effects in cancer cell lines with high c-Met protein expression.

E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells.

A tightly regulated catabolic process named autophagy involves the degradation of intracellular components via lysosomes. Here we investigate the antitumor effect of E Platinum, a newly synthesized derivative of oxaliplatin, in vivo and in vitro. E Platinum exhibits growth inhibition of various tumor cells in a dose-dependent manner, but the mechanism underlying it is unclear.

cis-1,2-Bis{[4-(4-pyrid-yl)pyrimidin-2-yl]sulfanylmeth-yl}benzene.

The mol-ecular skeleton of the title mol-ecule, C(26)H(20)N(6)S(2), adopts a cis conformation with the two arms positioned on one side of the benzene ring plane. Intra-molecular π-π inter-actions between the pyrimidine rings [centroid-centroid distance = 3.654 (2) Å] and between the pyridine rings [centroid-centroid distance = 3.

A polymeric ladder complex: catena-poly[[[micro-4,4'-bipyridyl-bis[aqua(p-aminobenzoato)copper(II)]]-di-mu-4,4'-bipyridyl] dinitrate tetrahydrate].

The title polymeric ladder complex, [[Cu(2)(C(7)H(6)NO(2))(2)(C(10)H(8)N(2))(3)(H(2)O)(2)](NO(3))(2).4H(2)O](n), has been synthesized and spectroscopically characterized. The polymeric nature of the compound involves two non-equivalent 4,4'-bipyridyl ligands acting as almost orthogonal bridges joining the metal coordination Jahn-Teller-distorted octahedra, and forming ladders packed under the influence of hydrogen bonds involving the uncoordinated amino group of the p-aminobenzoate ligand, the NO(3)(-) anion and the water molecules.

(1R,3S)-1-Monoamidocamphoric acid.

The title compound, (1S,3R)-3-carbamoyl-2,2,3-trimethylcyclopentane-1-carboxylic acid, C(10)H(17)NO(3), was synthesized and characterized by IR, EA, ES-MS (electrospray ionization mass spectra), (1)H NMR, (13)C NMR and X-ray diffraction techniques. The two independent molecules form a two-dimensional network via O-H.O and N-H.