[Seroepidemical study of Coxsackievirus A 16, in four provinces, China, 2005].

Objective: To study the situation of 1- 5-years-old children's antibody against Coxsackievirus A group 16 strain (CVA16) in Guangdong, Heilongjiang,Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005, it can offer scientific evidences for preventing and controlling CVA16 causative hand-food and mouth disease.

Methods: Using microneutrilization test, to study 503 serum samples randomly selected from sera collected in 2005.

Results: Positive rate of anti-CVA16 antibody were 41.

[Coxsackievirus A group 16 strain].

Coxsackievirus A group 16 strain (CVA16) is one of the predominate causative agent of the hand, foot and mouth disease (HFHD). It is very helpful to improve the hand, foot and mouth disease and other associated diseases control and prevention by understanding its biological characteristics, pathogenic mechanism and clinical manifestations, laboratory diagnoses, epidemiology and molecular epidemiology. In the future, we should continue to emphasize the study, improve the diagnostic method and develop vaccine of CVA16.