Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration.

Objective: This randomized controlled trial examined serum and macular (in vivo measured macular pigment optical density [MPOD]) responses to supplemental lutein and zeaxanthin in Chinese subjects with early age-related macular degeneration.

Methods: One hundred and eight patients with early age-related macular degeneration older than 50 y were randomized to low lutein (LL; 10 mg/d), high lutein (HL; 20 mg/d), lutein plus zeaxanthin (LZ; each 10 mg/d), or placebo during a 48-wk intervention. Serum concentrations were quantified by C(30) high-performance liquid chromatography (at baseline and 4, 12, 24, and 48 wk), and MPOD was measured by analysis of autofluorescence images (at baseline and 24 and 48 wk).

Effect of lutein and zeaxanthin on macular pigment and visual function in patients with early age-related macular degeneration.

Purpose: To determine whether supplementation with lutein and zeaxanthin improves macular pigment and visual function in patients with early age-related macular degeneration (AMD).

Design: Randomized, double-masked, placebo-controlled trial.

Participants: Participants with probable AMD who were 50 to 79 years of age were screened for study eligibility from the local communities.

Effects of dietary intervention on hyperlipidemia in eight communities of Beijing, China.

Objective: To examine the effect of community-based dietary intervention on hyperlipidemia.

Methods: A total of 180 hyperlipidemia individuals with TG>2.26 mmol x L(-1) (200 mg x dL(-1)) and/or TC>5.