Identification of a small molecule 1,4-bis-[4-(3-phenoxy-propoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53.

Aim: To identify novel small compound inhibitor of p53 protein.

Methods: Mouse embryonic fibroblasts (MEF) and mouse embryonic stem (ES) cells were tested. Cell proliferation rate was determined using a Cell Proliferation Kit.

[Geochemical character of precipitation in summer of Shanghai 2008-2009].

The chemical compositions of the rainwater collected in Shanghai in Summer of 2008-2009 were investigated. The chemical character and pollutant source of rainwater were evaluated depended on HYSPLIT model, ions tracer techniques, correlation and principal component analysis. The results showed that: (1) the mean pH in rain was 4.