Publications by authors named "Shao-Fan Wang"
Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity.
Ther Adv Endocrinol Metab
October 2024
Article Synopsis
- - The increase in global obesity has led to heightened research on adipocytes, focusing on stress factors like hypoxia and inflammation that cause organelle dysfunction, particularly in the endoplasmic reticulum (ER).
- - When excess nutrients are present, the ER experiences stress from improperly folded proteins, triggering a protective response called the unfolded protein responses (UPRs); failure of this response can result in cell damage.
- - Prolonged ER stress in adipocytes contributes to obesity-related issues, such as insulin resistance and increased fat breakdown, suggesting that targeting this stress could be an effective obesity treatment strategy.
Background/aims: The long-term renal outcomes of patients with IgA nephropathy (IgAN) who present with recurrent macroscopic hematuria (RMH) have not been described in previous studies.
Methods: Patients with biopsy-proven primary IgAN in Jinling Hospital were divided into three groups according to different patterns of macroscopic hematuria (MH): RMH, isolated MH (IMH), and those without a history of MH (NMH).
Results: A total of 1,155 patients were enrolled in the study (158 in the RMH group, 256 in the IMH group, and 741 in the NMH group).