RPUSD1 enhances the expression of eIF4E through RluA catalytic domain, activates PI3K/AKT signaling pathway, and promotes the cell proliferation and invasion in non-small cell lung cancer.

RNA pseudouridylate synthase domain containing 1 (RPUSD1) is a pseudouridine synthase, and its role in human solid tumors remains unknown. We found that RPUSD1 showed enhanced cytoplasmic expression in non-small cell lung cancer (NSCLC) using immunohistochemistry and western blotting. Its increased expression is associated with tumor malignant phenotypes.