Publications by authors named "Shao Nan Zhang"
Article Synopsis
- Thirteen transition metal complexes were synthesized and characterized, with a focus on their cytotoxic effects on A549/DDP cancer cells using various analytical techniques.
- Complexes 10-13 exhibited significantly stronger anti-cancer activity compared to complexes 1-9, with IC values ranging from 0.97 to 3.31 μM.
- Complexes 11 and 13 specifically induced apoptosis and autophagy through mitochondrial dysfunction, highlighting their potential as effective treatments for A549/DDP xenografts.
Five novel compounds, methyl 5-(acetyloxy)-1-(6-bromo-2-pyridinyl)-1-pyrazole-3-carboxylate (), methyl 1-(6-bromo-2-pyridinyl)-5-hydroxy-1H-pyrazole-3-carboxylate (), Trimethyl 1,1',1''-tris(6-bromo-2-pyridinyl)-5,5''-dihydroxy-5'-oxo-1',5'-dihydro-1H,1''H-4,4': 4',4''-terpyrazole-3,3',3''-tricarboxylate (H₂L¹, ), [Cu₂(L²)₂]·CH₃OH (), H₂L·CH₃CN () were synthesized. Compounds - characterized by elemental analysis, IR, and X-ray single-crystal diffraction. And - were also characterized by ¹H NMR, C NMR and ESI-MS.
View Article and Find Full Text PDFObjective: To investigate the synergism inhibition of curcumin combined with cisplatin on T24 bladder carcinoma cells and the down-regulating effect of curcumin on the Keapl-Nrf2 pathway, a well recognized anti-drug pathway in almost drugged tumor cells.
Methods: T24 cells were cultured and treated with increasing concentrations of curcumin(5 ,10 and 20 µmol/mL) combined with cisplatin(30 µg/mL) for 24 hours. The inhibitory effects on T24 cells were tested with MTI colorimetric assay.