Publications by authors named "Shao Dan Zhang"
Aim: To report a one-year clinical outcomes of low-dose laser cycloplasty (LCP) among malignant glaucoma patients.
Methods: In this prospective, multicenter, non-comparative clinical study, participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in China. Patients were followed up at 1wk, 1, 3, 6, and 12mo.
Aim: To assess glaucoma patient satisfaction and follow-up adherence in case management and identify associated predictors to improve healthcare quality and patient outcomes.
Methods: In this cross-sectional study, a total of 119 patients completed a Patient Satisfaction Questionnaire-18 and a sociodemographic questionnaire. Clinical data was obtained from the case management system.
Article Synopsis
- - The study aimed to evaluate the effectiveness of low-dose laser cycloplasty (LCP) in treating chronic angle-closure glaucoma (CACG), focusing on outcomes like intraocular pressure (IOP) and medication use.
- - Data from 7 CACG patients who underwent LCP revealed significant reductions in mean IOP (from 26.1 to 14.9 mm Hg) and the number of glaucoma medications (from 3.1 to 0.4) over an average follow-up of 27 months.
- - Results indicated improvement in anterior segment parameters, with most patients showing deepening of anterior chamber depth and reopening of the anterior chamber angle, suggesting LCP is a promising and safe treatment for CACG
Autoantibodies (AAbs) in the blood of colorectal cancer (CRC) patients have been evaluated for tumor detection. However, it remains uncertain whether these AAbs are specific to tumor-associated antigens. In this study, we explored the IgG and IgM autoantibody repertoires in both the in situ tissue microenvironment and peripheral blood as potential tumor-specific biomarkers.
View Article and Find Full Text PDFPrevious studies have demonstrated strong associations between host genetic factors and Epstein-Barr virus (EBV) VCA-IgA with the risk of nasopharyngeal carcinoma (NPC). However, the specific interplay between host genetics and EBV VCA-IgA on NPC risk is not well understood. In this two-stage case-control study (N = 4804), we utilized interaction and mediation analysis to investigate the interplay between host genetics (genome-wide association study-derived polygenic risk score [PRS]) and EBV VCA-IgA antibody level in the NPC risk.
View Article and Find Full Text PDFA comprehensive predictive model for radiation-induced brain injury in risk stratification and personalized radiotherapy of nasopharyngeal carcinoma.
Radiother Oncol
January 2024
Article Synopsis
- Radiation-induced brain injury (RBI) significantly impacts the quality of life and survival rates for patients with nasopharyngeal carcinoma (NPC), prompting the need for improved risk stratification tools.
- A large study involving 1189 NPC patients undergoing radiotherapy led to the development of a polygenic risk score (PRS) that effectively identifies individuals at high risk for RBI, with suggested adjusted radiation doses to minimize risk based on genetic predisposition.
- The integration of PRS with clinical factors enhanced prediction accuracy for RBI, indicating that personalized treatment strategies could be developed to optimize patient outcomes.
Article Synopsis
- Large-scale genetic studies found several genetic loci linked to nasopharyngeal carcinoma (NPC), prompting further investigation into biological mechanisms behind these associations.
- A follow-up study involving nearly 7,000 NPC cases and over 10,000 controls identified two new susceptibility loci (9q22.33 and 17q12) and confirmed the role of two previously known loci linked to NPC risk.
- Functional analyses revealed that the genes PHF2 and CDKN2B-AS1 at these loci are crucial for NPC development, with risk alleles affecting their expression levels and consequently promoting NPC cell proliferation.
Article Synopsis
- The study investigates the link between human leukocyte antigen (HLA) molecules that present Epstein-Barr virus (EBV) antigens and the risk of nasopharyngeal carcinoma (NPC).
- Researchers analyzed 455 NPC patients and 463 healthy individuals, using HLA-target sequencing and predictive modeling to assess how EBV peptides bind to different HLA supertypes.
- Results showed that specific EBV peptides have different binding affinities related to NPC risk, with one HLA supertype associated with higher risk and another offering a protective effect, highlighting the complex relationship between EBV, HLA, and NPC development.
Article Synopsis
- - Chemoradiation-induced hearing loss (CRIHL) significantly impacts the long-term quality of life for patients with nasopharyngeal carcinoma (NPC), with age, tumor stage, and cisplatin dosage being key risk factors identified in the study.
- - A genome-wide association study (GWAS) on 777 NPC patients found a specific genetic variant (rs1050851) linked to a 5.46-fold increased risk of hearing loss, indicating a potential genetic predisposition associated with the condition.
- - The research suggests a genetic overlap between hereditary deafness and CRIHL, emphasizing the role of synaptic signaling in hearing loss development and allowing for improved risk prediction for personalized prevention strategies.
Aim: To evaluate the trend of glaucoma internal filtration surgeries for inpatients between 2015 and 2021 at the Eye Hospital of Wenzhou Medical University.
Methods: A review of the medical records of inpatients who had been diagnosed with glaucoma and received anti-glaucoma surgery between January 1, 2015 and December 31, 2021 was conducted. The glaucoma diagnosis in this study included primary open angle glaucoma, primary angle-closure glaucoma, secondary glaucoma, and paediatric glaucoma.
Development and validation of a polygenic hazard score to predict prognosis and adjuvant chemotherapy benefit in early-stage non-small cell lung cancer.
Transl Lung Cancer Res
September 2022
Article Synopsis
- The study aimed to create a polygenic hazard score (PHS) to predict who would benefit from adjuvant chemotherapy (ACT) in patients with early-stage non-small cell lung cancer (NSCLC).
- It involved a retrospective analysis of 1,395 stage I-II NSCLC patients and included a genome-wide association study to derive the PHS from 37 specific genetic markers.
- The results showed that patients with a low PHS had significantly better outcomes with ACT, particularly stage II patients, suggesting that the PHS could help identify those most likely to benefit from chemotherapy.
Article Synopsis
- Researchers aimed to find genetic mutations that contribute to the risk of familial nasopharyngeal carcinoma (NPC) by studying 13 families with multiple cases of the disease.
- Whole-exome sequencing identified three rare mutations in the POLN gene that showed a strong association with familial NPC and affected the gene’s ability to support viral replication.
- The study concluded that the POLN gene is a susceptibility factor for familial NPC, with mutations leading to decreased protein stability and impaired viral function, highlighting its role in the disease's biology.
Article Synopsis
- Nasopharyngeal carcinoma (NPC) is linked to genetic factors and Epstein-Barr virus infection, making genetic counseling essential for high-risk families.
- A study involving whole-exome sequencing of 502 familial NPC patients revealed rare mutations in known cancer genes and identified 6 new susceptibility genes, with RAD54L showing the highest prevalence.
- Findings suggest that individuals with both rare and common genetic variants face significantly higher NPC risk, paving the way for better risk assessment and prevention strategies for those with a family history of the disease.
Aim: To report the outcomes of penetrating canaloplasty for corticosteroid-induced glaucoma in a case series.
Methods: Penetrating canaloplasty is a bleb-independent filtering surgery unifying canaloplasty and trabeculectomy. In this study, the surgery was performed to restore the natural outflow through surgically expanded Schlemm's canal and generated trabeculum ostium.
Article Synopsis
- - The study analyzed the EBV genomes of 38 patients with a family history of nasopharyngeal carcinoma (NPC) and 47 healthy controls to investigate the viral characteristics associated with familial NPC.
- - Researchers found mutation hotspots in the EBV latent gene regions of familial NPC cases and identified a specific genetic cluster that was significantly more common in these cases compared to controls.
- - Genome-wide association analysis revealed four variants linked to familial NPC, and a set of 34 high-risk EBV haplotypes correlated with an increased risk of familial NPC, suggesting EBV subtypes may play a role in the hereditary nature of the disease.
Article Synopsis
- Plasma Epstein-Barr virus (EBV) DNA load in oral samples is explored as a non-invasive biomarker in predicting outcomes for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).
- A study with 1,194 LA-NPC patients in south China revealed that higher oral EBV DNA levels (>2,100 copies/mL) correlate with poorer overall survival and other survival metrics.
- The findings suggest that measuring oral EBV DNA load could improve risk assessment alongside traditional TNM staging, potentially enhancing patient prognosis management.
Objective: To decipher the antidepressant targets and mechanisms of Huangqin (Radix Scutellariae Baicalensis) (RSB) by a novel computational system based on prediction and experimental verification.
Methods: The putative targets of RSB against depression were identified from Traditional Chinese Medicine Systems Pharmacology (TCMSP) and DrugBank. Next, protein-protein interaction network of the anti-depression targets of RSB were identified, and differentially expressed genes (DEGs) of depression were mined from the NCBI database.
Article Synopsis
- Epstein-Barr virus (EBV) is linked to pulmonary lymphoepithelioma-like carcinoma (pLELC), a rare lung cancer, but its genomic characteristics in relation to this cancer are not fully understood.
- A study analyzed whole-genome data from EBV isolated in 78 pLELC patients and 37 healthy controls, revealing 3,995 variations, particularly in latent genes, and identified 32 variations significantly associated with pLELC.
- The study established a global overview of EBV genomic profiles in pLELC patients, indicating that the EBV strains from pLELC are more similar to those found in nasopharyngeal carcinoma and showed
Objectives: This study aimed to assess the association between the corneal biomechanical parameters and visual field (VF) loss in patients with asymmetric primary open-angle glaucoma (POAG).
Methods: A total of 89 POAG patients (50 males, 56.2%) with asymmetric VF loss, aged 65.
Background: Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. Radiogenomics studies have indicated that genetic variants are associated with adverse effects of radiotherapy.
View Article and Find Full Text PDFEffects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression.
Evid Based Complement Alternat Med
December 2019
Background: Huazhuo Jiedu Shugan decoction (HJSD), a traditional Chinese medicine (TCM), has been used to treat epileptic seizures for many years. Some ingredients in these herbs have been demonstrated to be effective for the treatment of brain damage caused by epilepsy.
Aim Of The Study: The object of the study is to determine the effects of HJSD on cognitive and emotional disorders in a rat model of epilepsy.
DNA ligase III (LIG3) has been implicated in the etiology of cancer. However, few studies have accessed the association of LIG3 single nucleotide polymorphisms (SNPs) with gastric cancer risk, especially in Chinese population. The current study was undertaken to investigate contribution of LIG3 gene polymorphisms to gastric cancer risk.
View Article and Find Full Text PDFGlaucoma is a chronic optic neuropathy that could lead to permanent vision loss. Primary open-angle glaucoma (POAG) is the most common type of glaucoma, with elevated intraocular pressure (IOP) as a major risk factor. IOP is mainly regulated by trabecular meshwork (TM), an important component of the conventional aqueous humor (AH) outflow pathway.
View Article and Find Full Text PDFBackground: Several genome-wide association studies (GWASs) have identified strong associations between genetic variants in the human leukocyte antigen (HLA) region and nasopharyngeal carcinoma (NPC). However, given the complex LD pattern in this region, the causal variants and the underlying mechanism of how genetic variants in HLA contribute to NPC development is yet to be understood.
Methods: To systematically characterize the HLA variants and their relationship to NPC susceptibility, we fine-mapped the HLA genes based on the GWAS data of 1583 NPC cases and 972 healthy controls, using SNP2HLA with the Pan-Asian panel as references.