Publications by authors named "Shao Chen"

Background: There is growing evidence that the occurrence and severity of respiratory diseases in children are related to the concentration of air pollutants. Nonetheless, evidence regarding the association between short-term exposure to air pollution and outpatient visits for respiratory diseases in children remains limited. Outpatients cover a wide range of disease severity, including both severe and mild cases, some of which may need to be transferred to inpatient treatment.

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Unlabelled: Determining and comparing mitochondrial genomes (mitogenomes) are essential for assessing the diversity and evolution of mitochondria. Ciliates are ancient and diverse unicellular eukaryotes, and thus are ideal models for elucidating the early evolution of mitochondria. Here, we report on six new mitogenomes of spirotrichs, a dominant ciliate group, and perform comparative analyses on 12 representative species.

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Background: Androgen deprivation therapy (ADT) induces cellular senescence and tumor stasis, thus serving as the standard treatment for prostate cancer (PCa). However, continuous suppression of canonical androgen receptor signaling actually leads to the switch from androgen-responsive growth to androgen-independent growth, contributing to "escape" from this ADT-induced senescence (AIS) and, subsequently, the development of castration-resistant prostate cancer (CRPC). Unfortunately, the mechanism underlying this phenomenon remains elusive.

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Background: Macrophages are central to the orchestration of immune responses, inflammatory processes, and the pathogenesis of diabetic complications. The dynamic polarization of macrophages into M1 and M2 phenotypes critically modulates inflammation and contributes to the progression of diabetic nephropathy. Sodium-glucose cotransporter 2 inhibitors such as dapagliflozin, which are acclaimed for their efficacy in diabetes management, may influence macrophage polarization, thereby ameliorating diabetic nephropathy.

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Background: Dyskeratosis congenita is a rare genetic disease due to telomere biology disorder and characterized by heterogeneous clinical manifestations and severe complications. "Porto-sinusoidal vascular disease" has been recently proposed, according to new diagnostic criteria, to replace the term "idiopathic non-cirrhotic portal hypertension." TERT plays an important role in telomeric DNA repair and replication.

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The interactions between microplastic-derived dissolved organic matter (MPs-DOM) and heavy metals (Cu, Pb, and Cd) regulate the complex environmental transport behavior of pollutants in terrestrial and aquatic environments. In this study, fluorescence excited emission matrix spectroscopy combined with parallel factor analysis (EEM-PARAFAC) and electrospray ionization coupled Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) were employed to investigate the complexation mechanism of MPs-DOM with heavy metals, as well as the effects of different environmental occurrences of MPs-DOM on the transport behaviors of heavy metals in saturated porous medium. The findings demonstrated that MPs-DOM, particularly humic-like substances containing aromatic structures and various oxygen functional groups, could form stable complexes with heavy metals.

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In this study, natamycin nanoparticles were prepared by anti-solvent method, and natamycin nanoparticles/chitosan coating was prepared and investigated for the preservation of sweet cherry. The results of particle size showed that the prepared natamycin nanoparticles were nano-sized, with a particle size of 209 ± 10 nm. The results of scanning electron microscope (SEM) showed that the apparent morphology was a uniform spherical structure.

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Background: The current study aims to identify the key pathways and potential therapeutic targets for pulmonary arterial hypertension (PAH) and to further evaluate the anti-PAH effects of isorhamnetin.

Methods: The dataset of gene expression profiling for PAH (GSE113439) was downloaded from the gene expression omnibus (GEO) database. Isorhamnetin target genes were extracted from the comparative toxicogenomics database (CTD).

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Article Synopsis
  • This study aimed to explore the effectiveness of arthroscopic treatment for NeerⅡb distal clavicular fractures using a locking plate.
  • It involved 15 patients, mostly middle-aged, who underwent the surgery between June 2018 and September 2022, with significant improvements in pain and shoulder function measured through various scoring systems.
  • Results showed successful healing and notable recovery, indicating that this minimally invasive technique is a feasible option for treating this type of fracture.
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Objective: Extracellular matrix protein 1 (ECM1) serves as a gatekeeper of hepatic fibrosis by maintaining transforming growth factor-β1 (TGF-β1) in its latent form. ECM1 knockout (KO) causes latent (L) TGF-β1 activation, resulting in hepatic fibrosis with rapid mortality. In chronic liver disease (CLD), ECM1 decreases with increasing CLD severity.

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  • Porcine reproductive and respiratory syndrome (PRRS) is a major viral disease affecting pigs worldwide, with vaccination being crucial for its control.
  • In China, the NADC30-like PRRSV strain has become the dominant strain, and existing vaccines mainly protect against the older HP-PRRSV strain but are ineffective against NADC30-like.
  • This study developed a chimeric PRRSV vaccine strain (rGD-SX-5U2) that combines genes from both HP-PRRSV and NADC30-like PRRSV, showing promising results in protecting against both strains and improving swine health outcomes.
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  • Lumbar disc herniation (LDH) affects over 2% of the global population, with unclear causes and recurring issues, prompting research into brain activity for potential therapeutic insights.
  • The study examined brain function in LDH patients undergoing Spinal Manipulative Therapy (SMT) and found differences in brain activity compared to healthy individuals, particularly in low-frequency oscillations.
  • SMT was shown to significantly alleviate pain and dysfunction in LDH patients while improving brain connectivity patterns, suggesting a neurological perspective on LDH and potential avenues for new neurobiological therapies.
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  • * A variety of assays, including real-time PCR and Western blotting, were conducted on human prostate cancer cell lines to analyze β-catenin interactions and modifications, with a focus on the effects of an NDR1 activator called aNDR1 on metastasis in a mouse model.
  • * The research reveals that NDR1 promotes β-catenin degradation via FBXO11-mediated ubiquitination, inhib
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This study employs Mendelian randomization to investigate the causal relationships between dietary factors, gut microbiota, and urinary tract infections (UTIs). Our analysis revealed statistically significant associations, including high alcohol intake, cheese, and oily fish consumption with UTI risk, as well as links between UTI risk and specific gut microbiota, such as , , , and . Additionally, we observed associations with inflammatory markers, including C-Reactive Protein and Interleukin-6.

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Background: Dyslipidemia and abnormal cholesterol metabolism are closely related to coronary artery calcification (CAC) and are also critical factors in cardiovascular disease death. In recent years, the atherogenic index of plasma (AIP) has been widely used to evaluate vascular sclerosis. This study aimed to investigate the potential association of AIP between CAC and major adverse cardiovascular events (MACEs).

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  • Chemotherapy-induced peripheral neuropathy causes significant pain and decreases the effectiveness of chemotherapy, with duloxetine being the primary treatment option, though it has challenges.
  • The study investigates Huangqi Guizhi Wuwu Decoction, a traditional Chinese medicine, for its neuroprotective effects on nerve injury caused by cisplatin in PC12 cells.
  • Results showed that Huangqi Guizhi Wuwu Decoction significantly improved cell viability against cisplatin-induced damage and affected numerous genes involved in axon guidance, suggesting a potential treatment for chemotherapy-induced peripheral neuropathy.
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Accurate assessment of phenotypic and genotypic characteristics of bacteria can facilitate comprehensive cataloguing of all the resistance factors for better understanding of antibiotic resistance. However, current methods primarily focus on individual phenotypic or genotypic profiles across different colonies. Here, a Digital microfluidic-based automated assay for whole-genome sequencing of single-antibiotic-resistant bacteria is reported, enabling Genotypic and Phenotypic Analysis of antibiotic-resistant strains (Digital-GPA).

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Background: When massive necrosis occurs in acute liver failure (ALF), rapid expansion of HSCs called liver progenitor cells (LPCs) in a process called ductular reaction is required for survival. The underlying mechanisms governing this process are not entirely known to date. In ALF, high levels of retinoic acid (RA), a molecule known for its pleiotropic roles in embryonic development, are secreted by activated HSCs.

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Background: Parasites Entamoeba spp., Enterocytozoon bieneusi and Blastocystis are prevalent pathogens causing gastrointestinal illnesses in animals and humans. Consequently, researches on their occurrence, distribution and hosts are crucial for the well-being of both animals and humans.

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To enhance curcumin's application in photodynamic inactivation (PDI) of liquid foods, a supramolecular complex of biotin-modified β-cyclodextrin and curcumin (Biotin-CD@Cur) was synthesized. This complex significantly improves curcumin's solubility, stability, and PDI efficiency. Following PDI, Biotin-CD@Cur can be magnetically separated from the liquid matrix using streptavidin-coated magnetic beads (SA-MBs).

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Helicobacter pylori, a type of gram-negative bacterium, infects roughly half of the global population. It is strongly associated with gastrointestinal disorders like gastric cancer, peptic ulcers, and chronic gastritis. Moreover, numerous studies have linked this bacterium to various extra-gastric conditions, including hematologic, cardiovascular, and neurological issues.

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Clinical observations suggest that acute kidney injury (AKI) occurs in approximately 20-50% of hospitalized cirrhotic patients, suggesting a link between the liver and kidney. Bone morphogenetic protein 9 (BMP9) is a protein produced primarily by the liver and can act on other tissues at circulating systemic levels. Previous studies have demonstrated that controlling abnormally elevated BMP9 in acute liver injury attenuates liver injury; however, reports on whether BMP9 plays a role in liver injury-induced AKI are lacking.

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Vascular calcification is an important pathological change in a variety of disease states such as atherosclerosis (AS), diabetes, chronic kidney disease (CKD), hypertension, and is a strong predictor of cardiovascular events. The distribution and location of calcification in different vessels may have different clinical effects and prognosis. Therefore, the study of high-risk sites of vascular calcification will help us to better understand the prevention, diagnosis, and treatment of related diseases, as well as to evaluate the efficacy and prognosis.

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Article Synopsis
  • - The study examines a new species of soil ciliate, Lamtostyla paravitiphila, found in eastern China, focusing on its structure and development through live observations and staining techniques.
  • - Key morphological traits include multiple macronuclear nodules, no cortical granules, numerous adoral membranelles, cirri arrangements, and distinct dorsal kineties.
  • - The morphogenesis involves the initial formation of specific cirral anlagen, with certain cirri contributing more to this process than others, while molecular analysis shows that related Lamtostyla species do not form a monophyletic group.
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