Decreased stability of soil dissolved organic matter under disturbance of periodic flooding and drying in reservoir drawdown area.

Dissolved organic matter (DOM) constitutes the largest active carbon pool on earth, playing a crucial role in numerous biogeochemical processes. Understanding the molecular characteristics and chemical properties of DOM is essential for comprehending the global carbon cycle. However, there is a lack of systematic understanding regarding the influence of periodic flooding and drying, caused by reservoir operations, on the sources, characteristics and stability of soil DOM in the drawdown area, as well as the biotic and abiotic processes regulating DOM changes.

Impact of cascade reservoir on the sources of organic matter in sediments of Lancang river.

The construction of dams to intercept natural rivers constitutes the most severe human activity influencing the underlying surface. This study focuses on four cascade reservoirs of the Lancang River and explores their impact on the migration of organic matter in sediments. The research reveals significant spatial variations in total organic carbon (TOC) and total nitrogen concentrations in the sediments of the four reservoirs.

Coalescence characteristics of free-living and particle-attached bacteria in a cascade river-reservoir system: A case study of the Jinsha River.

Microbial coalescence plays a crucial role in shaping aquatic ecosystems by facilitating the merging of neighboring microbial communities, thereby influencing ecosystem structure. Although this phenomenon is commonly observed in natural environments, comprehensive quantitative comparative studies on different lifestyle bacteria involved in this process are still lacking. The study focuses on 16S rRNA Amplicon Sequence Variants (ASVs) at the Jinsha River hydropower stations (Wudongde [WDD], Baihetan [BHT], Xiluodu [XLD], Xiangjiaba [XJB]), specifically examining free-living (FL) and particle-attached (PA) bacteria.

Deciphering the impact of cascade reservoirs on nitrogen transport and nitrate transformation: Insights from multiple isotope analysis and machine learning.

Construction of cascade reservoirs has altered nutrient dynamics and biogeochemical cycles, thereby influencing the composition and productivity of river ecosystems. The Lancang River (LCR), characterized by its cascade reservoir system, presents uncertainties in nitrogen transport and nitrate transformation mechanisms. Herein, we conducted monthly monitoring of hydrochemistry and multiple stable isotopes (δN-NO, δO-NO, δO-HO, δD-HO) throughout 2019 in both the natural river reach (NRR) and cascade reservoirs reach (CRR) of the LCR.

Divergent contributions of microbes and plants to soil organic carbon in the drawdown area of a large reservoir: Impacts of periodic flooding and drying.

The distribution patterns and accumulation mechanisms of plant and microbial residues, along with their potential contributions to soil organic carbon (SOC), remain subjects of considerable debate, particularly within drawdown areas affected by reservoir operation. In this study, surface soil samples (0-10 cm) were collected from three different elevations within the drawdown area of the Three Gorges Reservoir. Amino sugars and lignin phenols served as biomarkers for microbial residues and plant-derived materials, respectively.

Targeting neutrophils extracellular traps, a promising anti-thrombotic therapy for natural products from traditional Chinese herbal medicine.

Thrombi are the main cause of vascular occlusion and contribute significantly to cardiovascular events and death. Neutrophils extracellular traps (NETs)-induced thrombosis plays a vital role in thrombotic complications and it takes the main responsibility for the resistance of fibrinolysis. However, the conventional anti-thrombotic therapies are inadequate to treat NETs-induced thrombotic complications but carry a high risk of bleeding.

Nitrate transformation and source tracking of Yarlung Tsangpo River using a multi-tracer approach combined with Bayesian stable isotope mixing model.

Excessive levels of nitrate nitrogen (NO-N) could lead to ecological issues, particularly in the Yarlung Tsangpo River (YTR) region located on the Qinghai Tibet Plateau. Therefore, it is crucial to understand the fate and sources of nitrogen to facilitate pollution mitigation efforts. Herein, multiple isotopes and source resolution models were applied to analyze key transformation processes and quantify the sources of NO.

Spatial variation of soil phosphorus in the water level fluctuation zone of the Three Gorges Reservoir: Coupling effects of elevation and artificial restoration.

The water level fluctuation zone (WLFZ) is a distinctive and important component of the reservoir ecosystem. Due to periodic inundation, the fraction, spatial distribution, and chemical reactivity of soil phosphorus (P) within the WLFZ can potentially impact the loading of P into reservoir waters. However, a detailed study of this subject is lacking.

Knowledge, Attitude, and Practice of Breast Cancer Patients Toward Lymphedema Complications: Cross-Sectional Study.

Breast cancer is commonly treated through surgical resection, but a common complication of the procedure is lymphedema of the upper limbs, which can significantly impact patients' daily life. This study aims to investigate the knowledge, attitude, and practice (KAP) of breast cancer patients with regard to lymphedema complications. This cross-sectional study was conducted by a self-administered questionnaire between August and October 2022 toward breast cancer patients in our Hospital of Traditional Chinese Medicine.

Community composition and abundance of complete ammonia oxidation (comammox) bacteria in the Lancang River cascade reservoir.

The construction of the reservoir has changed the nitrogen migration and transformation processes in the river, and a large amount of sediment deposition in the reservoir may also lead to the spatial differentiation of complete ammonia oxidation (comammox) bacteria. The study investigated the abundance and diversity of comammox bacteria in the sediments of three cascade reservoirs, namely, Xiaowan, Manwan, and Nuozhadu on the Lancang River in China. In these reservoirs, the average amoA gene abundance of clade A and clade B of comammox bacteria, ammonia-oxidizing archaea (AOA), and ammonia-oxidizing bacteria (AOB) was 4.

Nitrogen fixation of Cyndon dactylon: A possible strategy coping with long-term flooding in the Three Gorges Reservoir.

The Three Gorges Reservoir (TGR) is one of the largest hydropower projects around the world which greatly alters the ecological function of the original ecosystem. The riparian zone of TGR is subject to a frequent fluctuation of water level, leading to severe nitrogen loss by leaching. Cyndon dactylon, a perennial stress tolerant plant, is one of the dominant plant species in the riparian zone of TGR.

Niche differentiation of comammox Nitrospira in sediments of the Three Gorges Reservoir typical tributaries, China.

Complete ammonia oxidizer (Comammox) can complete the whole nitrification process independently, whose niche differentiation is important guarantee for its survival and ecological function. This study investigated the niche differentiation of comammox Nitrospira in the sediments of three typical tributaries of the Three Gorges Reservoir (TGR). Clade A and clade B of comammox Nitrospira coexisted in all sampling sites simultaneously.

Early Warning of Ischemic Stroke Based on Atherosclerosis Index Combined With Serum Markers.

Context: Ischemic stroke (IS) is a serious public health problem worldwide, threatening human life and health. Atherosclerosis is the cause of stroke. At present, there are few selective indexes that can be used to evaluate atherosclerosis in the clinic; providers rely mainly on the atherosclerotic index (AI).

The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis.

Meiosis is essential for fertility in sexually reproducing species and this sophisticated process has been extensively studied. Notwithstanding these efforts, key factors involved in meiosis have not been fully characterized. In this study, we investigate the regulatory roles of zinc finger protein 541 (ZFP541) and its interacting protein potassium channel tetramerization domain containing 19 (KCTD19) in spermatogenesis.

Study on Hepatotoxicity of Rhubarb Based on Metabolomics and Network Pharmacology.

Background: Rhubarb, as a traditional Chinese medicine, is the preferred drug for the treatment of stagnation and constipation in clinical practice. It has been reported that rhubarb possesses hepatotoxicity, but its mechanism in vivo is still unclear.

Methods: In this study, the chemical components in rhubarb were identified based on UPLC-Q-TOF/MS combined with data postprocessing technology.

ASBT(SLC10A2): A promising target for treatment of diseases and drug discovery.

Bile acids has gradually become a new focus in various diseases, and ASBT as a transporter responsible for the reabsorption of ileal bile acids, is a key hinge associated to the bile acids-cholesterol balance and bile acids of enterohepatic circulation. The cumulative studies have also shown that ASBT is a promising target for treatment of liver, gallbladder, intestinal and metabolic diseases. This article briefly reviewed the process of bile acids enterohepatic circulation, as well as the regulations of ASBT expression, covering transcription factors, nuclear receptors and gut microbiota.

Techniques and Strategies for Potential Protein Target Discovery and Active Pharmaceutical Molecule Screening in a Pandemic.

Viruses remain a major challenge in the fierce fight against diseases. There have been many pandemics caused by various viruses throughout the world over the years. Recently, the global outbreak of COVID-19 has had a catastrophic impact on human health and the world economy.

Asymmetric responses of spatial variation of different communities to a salinity gradient in coastal wetlands.

Various ecological communities are susceptible to the salinity gradients in coastal wetlands. Remane diagram has well described the macrozoobenthos diversity pattern along salinity gradients. Yet, further research is still needed, that is, the changes in diversity and biomass of other communities (e.

Establishing a rapid classification and identification method for the major triterpenoids of Alisma orientale.

Introduction: Alismatis Rhizoma (AR) has been widely used to treat various diseases. Its complex chemical composition has caused certain difficulties in the analysis of this traditional Chinese medicine. Therefore, it is necessary to establish a method for the rapid classification and identification of the chemical constituents of AR.

A comparison of coastal habitat restoration projects in China and the United States.

We compared coastal restoration projects in a developing country, China, and a developed country, the United States of America, both of which are facing loss and degradation of coastal habitats at similar latitudes, for the period of 1992-2014. To document the scale of coastal habitat restoration projects in the two countries, we identified 914 coastal restoration projects with an accumulated area of 300,521 acres in China, with most of our information coming from scientific papers, and 1,620 coastal restoration projects with an accumulated area of 243,064 acres in the USA, with most of our information coming from public databases. In both countries, about half the projects were in wetland habitats, but China had a greater proportion of projects in submerged habitats (43% versus 28% in the USA) and the USA a greater proportion in coastal upland habitats (21% versus 9% in China).

Tracing the sources of nitrate in the rivers and lakes of the southern areas of the Tibetan Plateau using dual nitrate isotopes.

Based on a quantitative analysis of nitrate concentrations, the nitrate sources and temporal variability of the rivers, lakes, and wetlands of Tibet were assessed for the first time using dual isotope technology. Water samples were collected once in July 2017 for analysis of nitrate concentration and isotopic composition. The overall values of δN-NO and δO-NO ranged from +1.

Studies on the activation of isocitrate dehydrogenase kinase/phosphatase (AceK) by Mn and Mg.

Isocitrate dehydrogenase kinase/phosphatase (AceK) is a bifunctional enzyme with both kinase and phosphatase activities that are activated by Mg. We have studied the interactions of Mnand Mg with AceK using isothermal titration calorimetry (ITC) combined with molecular docking simulations and show for the first time that Mn also activates the enzyme activities. However, Mn and Mg exert their effects by different mechanisms.

Analysing how plants in coastal wetlands respond to varying tidal regimes throughout their life cycles.

Important to conserve plant species in coastal wetlands throughout their life cycle. All life stages in these habitats are exposed to varying tidal cycles. It is necessary to investigate all life stages as to how they respond to varying tidal regimes.