Publications by authors named "Shanzay Ahmed"
Article Synopsis
- The study explores how a compound called c28MS can simultaneously inhibit glycolysis and glutaminolysis in rheumatoid arthritis synovial fibroblasts (RAFLS), potentially offering a new treatment strategy for the disease.
- Researchers used single-cell RNA sequencing (scRNA-seq) and metabolomic analysis to identify key metabolic pathways involved in RAFLS and found that c28MS reduced aggressive behavior in these cells and lowered arthritis severity in lab mice.
- The results suggest that targeting multiple metabolic pathways could be a promising therapeutic approach not only for rheumatoid arthritis but also for other non-cancer diseases.
Enhancement of glycolysis and glutaminolysis are the two most common modalities associated with metabolic reprogramming in rheumatoid arthritis (RA). This enhancement is concomitant to the upregulation of hexokinase 2 (HK2) and glutaminase 1 (GLS1). Hence, the current study was undertaken to identify potential phytobiological inhibitors against HK2 and GLS1, from , an indigenous ethnomedicinal plant found in Pakistan, using computational analysis.
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