Differential expression of microRNAs in bile duct obstruction-induced liver fibrosis and the identification of a novel liver fibrosis marker miR-1295b-3p.

Background: Bile duct obstruction-induced liver fibrosis is mainly caused by cholestatic liver injury which stimulates liver cell inflammation and damages the liver structure, causing liver fibrosis. The differentially expressed microRNAs and the potential target genes and signal pathways that are involved in bile duct obstruction-induced liver fibrosis remain unclear. We examined the differential expression of microRNAs and the target genes in the liver tissues of patients with liver fibrosis.

Long-term efficacy of radiofrequency ablation compared to surgical resection for the treatment of small hepatocellular carcinoma.

Purpose: To compare the clinical efficacy of surgical resection (SR) and radiofrequency ablation (RFA) for the treatment of small hepatocellular carcinoma (SHC; ≥ 5 cm in diameter).

Methods: The clinical and follow-up data for 88 patients with SHC, including 42 cases of SR and 46 cases of RFA, were analyzed.

Results: The mean follow-up time was 34.