Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives.

Osteoarthritis (OA) is one of the leading causes of disability worldwide, characterized by a complex pathological process involving cartilage degradation, synovial inflammation, and subchondral bone remodeling. In recent years, ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation, has been recognized as playing a critical role in the onset and progression of OA. Investigating the molecular mechanisms of ferroptosis and its involvement in OA may offer novel strategies for diagnosing and treating this disease.

Hypereosinophilic syndrome with massive liver infarction: A case report.

Rationale: Liver infarction caused only by hepatic artery occlusion is rare. Elevated levels of eosinophils in the blood and tissue can have devastating consequences.

Patient Concerns: Male, 21 years old, presented with persistent abdominal distension and discomfort for more than ten days without an apparent cause.