Publications by authors named "Shantong Qiu"
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Hepatocyte nuclear factor 4 alpha (HNF4α) and the pregnane X receptor (PXR) are involved in hepatocyte regeneration. It is not clear whether HNF4α is involved in hepatocyte regeneration through the regulation of PXR. This study aims to explore the regulatory relationship between HNF4a and PXR, and whether it affects hepatocyte regeneration.
View Article and Find Full Text PDFIn animal assisted reproductive technology, the production of high-quality oocytes is crucial. The yak, having lived in the Qinghai-Tibet Plateau for an extended period, has reproductive cells that are regulated by hypoxia-inducible factor 1α (HIF-1α). This study aimed to investigate the impact of HIF-1α on yak oocyte maturation and early embryonic development in vitro through the regulation of autophagy.
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- - PEDV is a harmful coronavirus affecting piglets, causing serious diarrhea and high death rates, which negatively impacts the global swine industry; a new strain from Tibetan pigs named CH/GS/2022 was isolated for study.
- - The study found that PEDV infections lead to varying levels of cell apoptosis that depend on the infection dose, with specific genes (p53, p38, JNK, Bax) showing increased expression and Bcl-2 showing decreased expression post-infection.
- - Using inhibitors, researchers demonstrated that p53 and p38 pathways are crucial in regulating PEDV-induced cell apoptosis, suggesting targeted treatments could mitigate the virus's effects on pig health.
Background: Porcine circovirus type 3 (PCV3) has been confirmed to infect pigs, posing a health risk and making pigs more susceptible to other pathogens. After the first report of PCV3 infection in the United States, its prevalence was determined in pigs suffering from clinical digestive or respiratory diseases in several other regions, including the Sichuan and Gansu provinces of China. In this study, we describe the frequency of PCV3 detection in Tibetan pigs inhabiting three different provinces surrounding the Qinghai-Tibet Plateau of China.
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