Inflammatory Myofibroblastic Tumor (IMT) of Gingiva: A Rare Clinical Entity.

Inflammatory myofibroblastic tumor (IMT) is an uncommon neoplasm that predominantly affects soft tissues and viscera. This abstract presents a unique case of IMT arising from the gingiva of a 32-year-old male. IMT is characterized by its variable clinical and clinic-histopathological presentation, often mimicking other malignancies, which can lead to diagnostic challenges.

A research agenda for encouraging prosocial behaviour on social media.

Many studies examine antisocial behaviours on social media-such as sharing misinformation or producing hate speech-but far fewer examine how platforms can incentivize more prosocial behaviour. We identify several ways in which social media platforms currently enable such behaviour, including (1) connecting new communities, (2) enabling collective problem-solving and (3) expanding the boundaries of philanthropy. However, we also discuss how some of the factors that enable prosocial behaviour can also empower malicious actors-as well as the challenge of creating prosocial behaviour that is sustainable and impactful offline.

Co-design and clinician evaluation of resources to address weight stigma in antenatal care.

Background: Weight stigma is a commonly reported experience in maternity care that negatively impacts the health of mothers and their babies. Knowledge to inform weight stigma reduction efforts in antenatal care is urgently required. This study aimed to co-design weight stigma reduction resources in antenatal care and evaluate clinician perspectives of the resources regarding their relevance to practice, strengths, and areas for improvement.

A swarm-optimization based fusion model of sentiment analysis for cryptocurrency price prediction.

Social media has attracted society for decades due to its reciprocal and real-life nature. It influenced almost all societal entities, including governments, academics, industries, health, and finance. The Social Network generates unstructured information about brands, political issues, cryptocurrencies, and global pandemics.

Examining Exercise-Related Cognitive Errors and Social Support for Physical Activity in Pregnancy.

Background: Worry about fetal health and lack of social support are commonly reported barriers to physical activity during pregnancy. Exercise-related cognitive errors (ECEs; eg, modifiable cognitions that cause individuals to catastrophize barriers to exercise) may have an independent association with physical activity and influence the relationship between social support and worry with physical activity. This study examined whether maternal-related worry, social support (from family and friends), ECEs, and their interactions differentiated the physical activity of pregnant individuals at 3 different levels: (1) active and meeting the prenatal physical activity guidelines, (2) active but not meeting the guidelines, and (3) inactive.

Suppression of NF-κB/NLRP3 by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation.

Binge alcohol use is increasing among aged adults (>65 years). Alcohol-related toxicity in aged adults is associated with neurodegeneration, yet the molecular underpinnings of this age-related sensitivity to alcohol are not well described. Studies utilizing rodent models of neurodegenerative disease reveal heightened activation of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Nod like receptor 3 (NLRP3) mediate microglia activation and associated neuronal injury.

Parachute-Like Mitral Valve and Associated Congenital Abnormalities Diagnosed With Multimodality Imaging.

• Asymmetric papillary muscles are seen in a parachute-like MV. • Parachute or parachute-like MV is associated with other congenital anomalies. • Multimodality imaging can identify concomitant congenital anomalies.

Use and safety of corticosteroid injections in joints and musculoskeletal soft tissue: guidelines from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, the American Society of Interventional Pain Physicians, the International Pain and Spine Intervention Society, and the North American Spine Society.

Background: Intra-articular corticosteroid (IACS) injection and peri-articular corticosteroid injection are commonly used to treat musculoskeletal conditions. Results vary by musculoskeletal region, but most studies report short-term benefit with mixed results on long-term relief. Publications showed adverse events from single corticosteroid injections.

Effect of Diabetes on Clinical Outcomes in Patients with Peripheral Arterial Disease undergoing Lower Extremity Revascularization: A Systematic Review and Meta-Analysis.

Introduction: Peripheral arterial disease (PAD) is highly prevalent and has a well-established association with diabetes mellitus (DM). However, it remains unclear whether DM worsens clinical outcomes after lower extremity revascularization (LER).

Methods: We performed a systematic search of six databases (Cochrane Library, Embase, Google Scholar, Medline, Scopus, and Web of Science) until February 2024, including studies that reported a risk estimate for the association of diabetes mellitus with 30-day all-cause mortality, hospital readmission, major amputation, and wound infection for patients following LER.

A complication of emergency caesarean section: delayed diagnosis of vesicouterine fistula with associated necrotising soft tissue infection and small bowel obstruction.

Vesicouterine fistula (VUF) is a rare complication following caesarean sections, often presenting with the classic triad of Youssef syndrome (urinary incontinence with cyclic haematuria (menouria) and amenorrhoea) but sometimes without typical symptoms. We report a case of a woman in her early 30s who developed VUF after an emergency lower segment caesarean section, complicated by necrotising soft tissue infection (NSTI) of the left forearm. One week post-surgery, she presented with NSTI symptoms and haematuria, which were managed with broad-spectrum antibiotics and debridement.

A multi-institutional retrospective cohort of adult-onset medulloblastoma in the modern era.

Background: Adult onset medulloblastoma (aMB) is a rare tumor with limited available evidence. We present a large multi-institutional retrospective cohort of aMB patients treated in the modern era, with an emphasis on understanding the role of chemotherapy at initial diagnosis.

Methods: We included 267 consecutive patients with aMB treated at 7 different institutions from 2000-present, controlling for chemotherapy regimen and cycles received.

Prognostic Value of G8 Geriatric Screening and Meet-URO Scores in Metastatic Renal Cell Carcinoma Patients Receiving First-Line Ipilimumab-Nivolumab Combination Immunotherapy.

Background: The prognostic value of the Geriatric 8 (G8) screening score in metastatic renal cell carcinoma (mRCC) patients receiving first-line immunotherapy remains unclear. This study aimed to evaluate the prognostic role of G8 within the context of the Meet-URO classification in mRCC patients treated with first-line ipilimumab-nivolumab.

Methods: This retrospective multicentre study analysed 106 mRCC patients treated with first-line ipilimumab-nivolumab.

Investigating Reddit Data on Type 2 Diabetes Management During the COVID-19 Pandemic Using Latent Dirichlet Allocation Topic Modeling and Valence Aware Dictionary for Sentiment Reasoning Analysis: Content Analysis.

Background: Type 2 diabetes (T2D) is a chronic disease that can be partially managed through healthy behaviors. However, the COVID-19 pandemic impacted how people managed T2D due to work and school closures and social isolation. Moreover, individuals with T2D were at increased risk of complications from COVID-19 and experienced worsened mental health due to stress and anxiety.

From screening to validation in zebrafish - a framework for reeling in the right psychobiotics.

The potential of gut bacteria to interact with the nervous system is now well known. Therefore, the characterization of bacterial strains that can modulate signalling pathways of the nervous system is a topic of growing interest, as it represents a potential alternative therapeutic target to treat central nervous system disorders. However, a streamlined screening framework is required to guide the rational identification and selection of such bacteria, known as psychobiotics.

How are exercise professionals described within academic literature? A narrative review.

There is growing interest to include exercise into healthcare for the prevention, treatment, and management of chronic disease. However, what defines an "exercise professional" to fulfil these roles and responsibilities is not clear across Canada. While exercise science often integrates exercise professionals within academic studies to assist exercise-based research, exploring how exercise professionals are involved in these contexts may contribute to developing a clearer understanding of how these professionals may be characterized.

Evaluating the Shear Bond Strength of Repaired Composites Using Different Surface Treatments and Repair Materials: An Comparative Study.

Introduction: Composite resin is commonly used in dental restorations, though it is prone to degradation over time. Repairing these restorations is often preferable for issues such as discoloration, small areas of decay near the restoration margin, or for preserving tooth health without the need for complete removal.

Method: Sixty acrylic blocks with cavities were restored using FILTEK-Z-250 XT composite resin, which was then light-cured.

Venoarterial Extracorporeal Membrane Oxygenation in Adults With Septic Shock: Hope or Hype?

Septic shock is associated with significant morbidity and mortality, but a subset of patients with sepsis will experience transient myocardial depression, termed sepsis-associated cardiomyopathy, which markedly increases observed mortality. Although venoarterial extracorporeal membrane oxygenation (VA-ECMO) can provide temporary mechanical circulatory support in medically refractory sepsis, survival in patients with VA-ECMO for sepsis has been historically poor. Concerns regarding numerous potential harms associated with VA-ECMO, including further seeding of infection, exacerbation of inflammation and vasoplegia, bleeding, thrombosis, and distal limb ischemia have further tempered enthusiasm in the setting of sepsis.

Systematic Review and Network Meta-Analysis on Treating Hormone Receptor-Positive Metastatic Breast Cancer After CDK4/6 Inhibitors.

Introduction: The optimal treatment of estrogen receptor-positive (ER +) metastatic breast cancer (MBC) after progression on cyclin-dependent 4/6 kinase inhibitors (CDK4/6i) is unknown.

Methods: We conducted a systematic review and network meta-analysis (NMA) of phase-II/-III randomized trials of ER + MBC post CDK4/6i + ET progression. We calculated the hazard ratio (HR) for progression-free survival (PFS) and overall survival (OS) using generic inverse variance and odds ratios (ORs) using the Mantel-Haenszel method for adverse events (AEs) with Review-Manager version-5.

Gadopiclenol Enables Reduced Gadolinium Dose While Maintaining Quality of Pulmonary Arterial Enhancement for Pulmonary MRA: An Opportunity for Improved Safety and Sustainability.

Rationale And Objectives: Pulmonary magnetic resonance angiography (MRA) is an imaging method with proven utility for the exclusion of pulmonary embolism and avoids the need for ionizing radiation and iodinated contrast agents. High-relaxivity gadolinium-based contrast agents (GBCAs), such as gadopiclenol, can be used to reduce the required gadolinium dose for pulmonary MRA. The aim of this study was to compare the contrast enhancement performance of gadopiclenol with an established gadobenate dimeglumine-enhanced pulmonary MRA protocol.

Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance.

Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often drug-resistant nosocomial pathogen, can colonize the GI tract asymptomatically, serving as an infection reservoir. To provide insight on how K.

ASRA Pain Medicine consensus practice infection control guidelines for regional anesthesia and pain medicine.

Background: To provide recommendations on risk mitigation, diagnosis and treatment of infectious complications associated with the practice of regional anesthesia, acute and chronic pain management.

Methods: Following board approval, in 2020 the American Society of Regional Anesthesia and Pain Medicine (ASRA Pain Medicine) commissioned evidence-based guidelines for best practices for infection control. More than 80 research questions were developed and literature searches undertaken by assigned working groups comprising four to five members.

Perspectives of Midwives and Nurse Practitioners in Kentucky on Exercise Counseling During Pregnancy: A Qualitative Study.

Introduction: Healthcare professionals are in an optimal position to deliver exercise information to pregnant women, yet previous research suggests this seldom happens. Midwives and nurse practitioners, who may have more time with pregnant women, are particularly well suited for this role.

Objectives: This qualitative study examined the exercise advice and counseling provided by midwives and nurse practitioners in Kentucky, focusing on the barriers they face.