Publications by authors named "Shantipriya Kakati"
Article Synopsis
- Gallbladder cancer (GBC) is a life-threatening disease with poor outcomes, and the study focuses on the role of oxidative stress and the base excision repair (BER) pathway in its development, especially in the North-East Indian population, where cases are rising.
- The research found that oxidative stress levels, indicated by 8-OH-dG, were significantly elevated in patients with gallbladder issues like cholelithiasis and cholecystitis, correlating with the severity of GBC.
- Key BER pathway genes were downregulated in GBC patients, and specific genetic polymorphisms were associated with both disease susceptibility and severity, suggesting that targeting oxidative stress markers and BER genes might offer new therapeutic strategies
