Publications by Shanti K Gore

Publications by authors named "Shanti K Gore"

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Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.

Petr Tomek Shanti K Gore Chloe L Potts Cristin G Print Michael A Black

Cell Commun Signal

November 2018

Background: Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer cells in the same microenvironment appear not to be affected. Mechanisms whereby cancer cells resist accelerated tryptophan degradation are not completely understood.

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