Publications by authors named "Shanthi V. Sitaraman"
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Synopsis of recent research by authors named "Shanthi V. Sitaraman"
- Shanthi V. Sitaraman's research primarily focuses on the mechanisms of inflammation and their implications in gastrointestinal disorders, particularly inflammatory bowel disease (IBD) and obesity, highlighting the roles of neuroimmune interactions and molecular factors in these conditions.
- Key findings include the protective effects of glial cell line-derived neurotrophic factor (GDNF) against diet-induced obesity, the regulation of inflammation and colonic motility through neuropeptide Y and tumor necrosis factor interactions, and the involvement of matrix metalloproteinases (MMPs) in exacerbating colitis.
- Sitaraman's work also explores the therapeutic potential of targeted drug delivery systems, such as anti-inflammatory nanoparticles, and the modulation of intestinal epithelium functions by microRNAs in response to colitis, suggesting innovative approaches to treat gastrointestinal inflammation.
