Composition-Tunable Ultrasmall Manganese Ferrite Nanoparticles: Insights into their T Contrast Efficacy.

The development of a highly efficient, low-toxicity, ultrasmall ferrite nanoparticle-based T contrast agent for high-resolution magnetic resonance imaging (MRI) is highly desirable. However, the correlations between the chemical compositions, T relaxivities, nano-bio interactions and toxicities remain unclear, which has been a challenge in optimizing the T contrast efficacy. : Ultrasmall (3 nm) manganese ferrite nanoparticles (MnFeO) with different doping concentrations of the manganese ions (x = 0.

Dishevelled 1, a pivotal positive regulator of the Wnt signalling pathway, mediates 5-fluorouracil resistance in HepG2 cells.

Acquired resistance to 5-fluorouracil (5-FU) frequently occurs in patients with hepatocellular carcinoma (HCC), the underlying molecular mechanisms of which are poorly understood. The aim of this study was to identify candidate genes and associated signalling pathways that may play a role in developing drug resistance following repeated 5-FU treatments. In this work, we established 5-FU-resistant cells (HepG2/5-FU) using stepwise increasing concentrations of 5-FU in parental HepG2 cells.