Publications by authors named "Shanshen Yu"
Article Synopsis
- Hyperphosphatemia is a common issue in end-stage renal disease (ESRD) patients, and current phosphate binders are not effectively managing serum phosphate levels.
- This meta-analysis reviewed data from multiple sources and included seven randomized controlled trials (RCTs) with 877 participants to evaluate the efficacy and safety of a medication called tenapanor.
- Results showed that tenapanor significantly lowered serum phosphorus levels compared to placebo and increased the number of patients reaching target phosphorus levels, while having an acceptable safety profile.
Article Synopsis
- Gitelman syndrome (GS) is a rare genetic disorder causing salt loss in the kidneys, but a patient with GS was newly diagnosed with hypercalcemia and primary hyperparathyroidism (PHPT).
- The patient had a long history of low potassium and magnesium levels, and lab tests confirmed GS alongside PHPT, highlighted by parathyroid hyperplasia.
- Treatment improved her potassium levels and joint pain, but managing her magnesium levels remained difficult due to increased urinary excretion caused by PHPT.
A review of progress on complement and primary membranous nephropathy.
Medicine (Baltimore)
July 2024
Primary membranous nephropathy (PMN) is a predominant cause of adult nephrotic syndrome, with its incidence witnessing a progressive surge over time. Approximately 35% to 47% of patients progress to renal failure within 10 years, causing a huge social burden. Within China, the proportion of PMN in primary glomerular disease exhibits a gradual ascension.
View Article and Find Full Text PDFEfficacy and Adverse Effects of Atrasentan in Patients with Diabetic Nephropathy: A Meta-Analysis.
Altern Ther Health Med
January 2024
Background: About 30% of Type 1 diabetes (T1DM) patients and 40% of Type 2 diabetes (T2DM) patients were diagnosed with diabetic nephropathy, which has also greatly affected the global end-stage renal disease (ESRD) outcome. Atrasentan is a selective endothelin receptor type A (ETA) antagonist initially studied for the potential treatment of cancer. However, the role of Atrasentan was not sure in the DM.
View Article and Find Full Text PDFBackground: Gitelman syndrome (GS) is a rare autosomal recessive inherited salt-losing tubulopathy (SLT). Here, we report, for the first time, a case of GS overlapping nephrotic syndrome (NS) related to PLA2R-associated membranous nephropathy (MN).
Case Presentation: We described a male patient had a 4-year history of recurrent fatigue.
Wnt4 is a secreted growth factor associated with renal tubulogenesis. Our previous studies identified that renal and urinary Wnt4 are upregulated following ischemia-reperfusion injury in mice, but the roles of Wnt4 in other forms of acute kidney injury (AKI) remain unclear. Here, we investigated the changes in Wnt4 expression using a cisplatin-induced AKI model.
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