Functional polymorphisms of the lncRNA promoter region contribute to the cancer risk and clinical outcomes in advanced colorectal cancer.

Background: The long non-coding RNA plays critical roles in cancer occurrence, development, and progression. The present study is for the first time to evaluate the association of genetic variations in the promoter region with advanced colorectal cancer (CRC) susceptibility, environmental factors, and clinical outcomes.

Methods: 16 single-nucleotide polymorphisms (SNPs) were identified in the gene promoter by DNA sequencing, and 3 SNPs among which including rs4930101, rs11042170, and rs2735970 further expanded samples with 572 advanced CRC patients and 555 healthy controls.

Associations of mRNA expression of DNA repair genes and genetic polymorphisms with cancer risk: a bioinformatics analysis and meta-analysis.

A systematical bioinformatics and meta-analysis were carried out to establish our understanding of possible relationships between DNA repair genes and the development of cancer. The bioinformatics analysis confirmed that lower and levels and higher , , and levels were observed in 19 types of cancer, and subsequently results indicated that elevated and had a better impact on overall survival, however, higher , , and showed worse influence on cancer prognosis. The meta-analysis included 58 eligible studies demonstrated that harboring rs10817938, rs238406 increased overall cancer risk, however, rs2808668 SNP in overall cancer analysis and rs3136038 in the digestive system remarkably reduced the cancer risk.

Combining Red Blood Cell Distribution Width (RDW-CV) and CEA Predict Poor Prognosis for Survival Outcomes in Colorectal Cancer.

: Colorectal cancer is one of the common tumors that seriously threaten human health worldwide. Serum tumor markers, including CEA and CA19-9, have become the focus of research on colorectal cancer in recent years. As one of the classic blood test results, RDW is related to the pathological features, diagnosis and prognosis of various cancers in recent studies.

Polymorphisms in DNA repair pathway genes and gene in advanced colorectal cancer: correlation with tumor characteristics and clinical outcome in oxaliplatin-based chemotherapy.

Objective: Multiple factors are involved in oxaliplatin-resistant process in colorectal cancer (CRC) patients including decreased drug accumulation and enhanced capacity to repair and tolerate DNA damage. In the present study, we aimed to assess the impact of six single-nucleotide polymorphisms (SNPs) in DNA repair genes and gene on prognosis in advanced CRC patients treated with oxaliplatin-based chemotherapy.

Methods: In this study, 580 advanced CRC patients were recruited.

Long noncoding RNA H19 promotes vascular remodeling by sponging let-7a to upregulate the expression of cyclin D1.

Vascular remodeling is mainly caused by excessive proliferation of vascular smooth muscle cells (VSMCs). Noncoding RNAs (ncRNAs) have emerged as important regulators in diverse pathological processes. Previous work has shown the functions and mechanisms of long noncoding RNA H19 (LncRNA H19) on VSMCs.