Publications by authors named "Shannon Zheng"
JCI Insight
November 2022
Article Synopsis
- Acquired aplastic anemia (AA) is primarily caused by the destruction of early blood cells by autoreactive T cells, with some patients showing immune escape through the loss of specific HLA class I alleles.
- In a study involving 505 AA patients, researchers identified 19 risk HLA alleles and 12 non-risk alleles, enhancing the understanding of HLA pathogenicity in the context of AA across different populations.
- Although certain HLA alleles increase the risk of developing AA, they do not affect treatment responses, but higher-risk alleles, like HLA-B*14:02, correlate with increased clonal evolution in patients.
