The air-breathing Alaska blackfish () remodels ventricular Ca cycling with chronic hypoxic submergence to maintain ventricular contractility.

The Alaska blackfish () is a facultative air-breather endemic to northern latitudes where it remains active in winter under ice cover in cold hypoxic waters. To understand the changes in cellular Ca cycling that allow the heart to function in cold hypoxic water, we acclimated Alaska blackfish to cold (5 °C) normoxia or cold hypoxia (2.1-4.