Publications by authors named "Shannon Roberson"
Perturbation of the developmental potential of preimplantation mouse embryos by hydroxyurea.
Int J Environ Res Public Health
May 2010
Women are advised not to attempt pregnancy while on hydroxyurea (HU) due to the teratogenic effects of this agent, based on results obtained from animal studies. Several case reports suggest that HU may have minimal or no teratogenic effects on the developing human fetus. Fourteen cases of HU therapy in pregnant patients diagnosed with acute or chronic myelogenous leukemia, primary thrombocythemia, or sickle cell disease (SCD) have been reported.
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- - Two experiments examined whether male transgenic sickle cell mice exhibit reproductive issues similar to those in men with sickle cell disease, particularly looking for signs of hypogonadism and how hydroxyurea (HU) treatment affects this condition.
- - Blood samples and sperm quality metrics were analyzed from sickle cell mice and control mice, revealing that sickle cell mice had significantly lower testosterone levels, testis weight, and sperm quality measures compared to controls, indicating they were experiencing hypogonadism.
- - In the second experiment, administering HU resulted in a significant decrease in testis weight and size over 28 and 56 days, highlighting that HU exacerbates reproductive issues in transgenic sickle cell mice.
Effects of benzo(a)pyrene on intra-testicular function in F-344 rats.
Int J Environ Res Public Health
March 2008
The objective of this study was to evaluate the reproductive risk associated with exposure of adult male Fisher-344 (F-344) rats to inhaled benzo(a)pyrene (BaP), a ubiquitous environmental toxicant present in cigarette smoke, automobile exhaust fumes and industrial emissions. Rats were assigned randomly to a treatment or control group. Treatment consisted of exposure of rats via nose-only inhalation to 75 microg BaP/m3, 4 hours daily for 60 days, while control animals were unexposed (UNC).
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