Publications by authors named "Shannon McSain"
Our phase 1 graft-versus-host disease (GVHD) prevention trial of JAK2 inhibitor, pacritinib (PAC; recommended phase 2 dose: 100 mg orally twice a day on day 0 to +70) plus sirolimus and tacrolimus (SIR/TAC) demonstrated the regimen was safe and free of pan-JAK myelosuppression after allogeneic hematopoietic cell transplantation (alloHCT). PAC inhibits interleukin 6 (IL-6) receptor activity and pathogenic T helper cell 1 (Th1)/Th17 differentiation in preclinical models and the phase 1 trial. Herein, we report on our completed phase 2 trial of PAC/SIR/TAC after 8/8 human leukocyte antigen matched alloHCT.
View Article and Find Full Text PDFBilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures.
Alcohol Clin Exp Res (Hoboken)
August 2024
Article Synopsis
- - The study investigates how the insular cortex (IC) influences rats' sensitivity to the negative effects of ethanol, particularly in terms of conditioned taste (CTA) and place avoidance (CPA) responses.
- - Rats with lesions in the IC showed weaker responses to ethanol, failing to demonstrate significant avoidance behaviors compared to neurologically intact rats, indicating the IC's crucial role in processing these adverse effects.
- - Findings suggest that proper functioning of the IC is essential for detecting and responding to the negative sensations associated with ethanol consumption, which might be affected by chronic alcohol use.
Background: Intermittent access to ethanol drives persistent escalation of intake and rapid transition from moderate to compulsive-like drinking. Intermittent ethanol drinking may facilitate escalation of intake in part by altering aversion-sensitive neural substrates, such as the insular cortex (IC), thus driving greater approach toward stimuli previously treated as aversive.
Methods: We conducted a series of experiments in rats to examine behavioral and neural responses associated with escalation of ethanol intake.