Publications by authors named "Shannon M Loncar"
Article Synopsis
- Our research revealed that 40% of human metastatic melanomas have inhibitory Fc gamma receptors (FcgammaRIIB), unlike less than 5% in primary melanomas and none in healthy melanocytes.
- These FcgammaRIIB function as decoy receptors, binding to cancer-fighting IgG antibodies and hindering the immune system's ability to target the melanoma.
- A notable 70% of melanomas in the liver express FcgammaRIIB, blocking natural killer cells' ability to attack the tumor, highlighting the need for improved anti-melanoma antibody therapies.
During melanoma progression, patients develop anti-tumor immunity including the production of anti-tumor antibodies. Although the strategies developed by malignant cells to escape anti-tumor cellular immunity have been extensively investigated, little is known about tumor resistance to humoral immunity. The main effect of IgG antibodies is to activate the immune response by binding to host Fc gamma receptors (FcgammaR) expressed by immune cells.
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