A dedicated surgical team for posterior spinal fusion in patients with adolescent idiopathic scoliosis improves OR efficiency.

Purpose: Standardized care pathways for adolescent idiopathic scoliosis (AIS) patients undergoing PSF improve clinical outcomes. We hypothesized that having dedicated spine personnel would decrease surgical time and improve clinical outcomes.

Methods: 367 patients with AIS had a PSF within a standardized perioperative care pathway.

Scoliosis Screening.

The national recommendations for school screening programs for scoliosis in the United States have undergone a shift in perspective over the past two decades. In 2004, the United States Preventive Services Task Force recommended against screening programs but changed its recommendation to be inconclusive in 2018. Early diagnosis of scoliosis can allow for close monitoring of the deformity and early initiation of bracing treatment when appropriate, with the goal of preventing costly and invasive surgical intervention.

Comparison of shoulder internal rotation passive range of motion in various positions in nonathletic persons and the establishment of normative values for the sidelying position.

Background: Loss of shoulder internal rotation (IR) range of motion (ROM) is prevalent in overhead athletes, but it can also be seen in nonathletic persons. A paucity of normative data exists, however, for shoulder IR ROM in positions other than supine, especially in nonathletic persons. The aim of this study was to determine shoulder IR ROM differences between the sidelying, semi-sidelying, and supine positions as well as to establish initial normative values for IR ROM for the sidelying and semi-sidelying positions in nonathletic persons.

TOTAL ARC OF MOTION IN THE SIDELYING POSITION: EVIDENCE FOR A NEW METHOD TO ASSESS GLENOHUMERAL INTERNAL ROTATION DEFICIT IN OVERHEAD ATHLETES.

Background: Total arc of motion (TA) measured in a supine position has been utilized as a method to detect the presence of glenohumeral internal rotation deficit (GIRD) in overhead athletes. A component of supine TA is supine internal rotation (IR) range of motion (ROM), which has many variables including the amount and location of manual stabilization. A sidelying position for gathering IR ROM has recently been proposed and, when combined with supine external rotation (ER) ROM, constitutes a new method of quantifying TA.

Prenatal diagnosis of musculoskeletal conditions.

Ultrasonography is a safe, cost-effective tool used to prenatally detect common musculoskeletal conditions, including clubfoot, skeletal dysplasias, limb-length discrepancies, spinal abnormalities, and hand and other upper extremity deformities. With increased detection of such abnormalities, prenatal parental counseling by orthopaedic surgeons is being requested more frequently. Counseling is important for family education on prognosis and treatment options.

Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens.

Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing.

Characterizing the in vitro hepatic biotransformation of the flame retardant BDE 99 by common carp.

Polybrominated diphenyl ethers (PBDEs) are a class of flame retardant chemicals known to biomagnify in aquatic foodwebs. However, significant biotransformation of some congeners via reductive dehalogenation has been observed during in vivo and in vitro laboratory exposures, particularly in fish models. Little information is available on the enzyme systems responsible for catalyzing this metabolic pathway in fish.

Latent mortality of juvenile snapping turtles from the Upper Hudson River, New York, exposed maternally and via the diet to polychlorinated biphenyls (PCBs).

We conducted a factorial experiment to compare sublethal and lethal responses of juvenile snapping turtles exposed maternally and/or through the diet to polychlorinated biphenyls (PCBs) over 14 months posthatching. Maternal exposure did not affect embryonic development or hatching success. Thyrosomatic indices were not influenced by treatments, although hepatosomatic indices were lower in animals having been exposed to PCBs maternally relative to those having been exposed both maternally and via the diet.

In vitro hepatic metabolism of 2,2',4,4',5-pentabromodiphenyl ether (BDE 99) in Chinook salmon (Onchorhynchus tshawytscha).

Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that persist in the environment and are present in geographically widespread fish species. PBDE concentrations can be particularly high in resident Chinook salmon (Onchorhynchus tshawytscha) in the Puget Sound, Washington. Although PBDE residues in salmon and other fish are often dominated by lower brominated congeners, these congeners are not produced commercially in the greatest quantity, suggesting bioaccumulation of the lower molecular weight PBDEs or debromination of more fully brominated congeners.

Metabolism of polybrominated diphenyl ethers (PBDEs) by human hepatocytes in vitro.

Background: Polybrominated diphenyl ethers (PBDEs) are flame-retardant chemicals that accumulate in human tissues and are potential toxicants. Concentrations of PBDEs in human tissues have increased recently, and body burdens in the U.S.

Alternate and new brominated flame retardants detected in U.S. house dust.

Due to the voluntary withdrawals and/or bans on the use of two polybrominated diphenyl ether (PBDE) commercial mixtures, an increasing number of alternate flame retardant chemicals are being introduced in commercial applications. To determine if these alternate BFRs are present in indoor environments, we analyzed dust samples collected from 19 homes in the greater Boston, MA area during 2006. Using pure and commercial standards we quantified the following brominated flame retardant chemicals using GC/ECNI-MS methods: hexabromocyclododecane (sigma HBCD), bis(2,4,6,-tribromphenoxy)ethane (BTBPE), decabromodiphenyl ethane (DBDPE), and the brominated components found in Firemaster 550 (FM 550): 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (TBB) and (2-ethylhexyl)tetrabromophthalate (TBPH), the latter compound being a brominated analogue of di(2-ethylhexyl)phthalate (DEHP).

Accumulation and maternal transfer of polychlorinated biphenyls in snapping turtles of the upper Hudson River, New York, USA.

We conducted field studies over three years to assess body burdens and maternal transfer of polychlorinated biphenyls (PCBs) as well as indices of sexual dimorphism in snapping turtles (Chelydra serpentina) of the upper Hudson River (NY, USA.) We collected adult turtles in areas known to be contaminated with PCBs and in nearby reference areas for measurement of body size, precloacal length, and penis size. We analyzed PCB concentrations in eggs collected over three years and in whole blood from adults in one year.

Measurement of polybrominated diphenyl ethers on hand wipes: estimating exposure from hand-to-mouth contact.

Estimates of exposure to the flame-retardant polybrominated diphenyl ethers (PBDEs) in dust are very poor due to limited knowledge about dust ingestion. This study was undertaken to determine if PBDEs could be measured on hand wipes, and if so, to determine the distribution of levels present on the skin surface area to provide preliminary exposure estimates from hand-to-mouth contact. Hand wipes were collected from 33 individuals residing in the United States using sterile gauze pads soaked in isopropyl alcohol.