Publications by authors named "Shannon J Nguyen"
Article Synopsis
- The study investigates how repeated administration of a metabotropic glutamate receptor 5 positive allosteric modulator (CDPPB) affects anti-psychotic-like effects in a rat model of schizophrenia.
- CDPPB acutely reduces amphetamine-induced hyperlocomotion, but with repeated dosing over 7 days, the effects vary by brain region, showing tolerance in the frontal cortex but not in the striatum.
- These findings highlight that receptor desensitization is region-specific and may influence both sleep architecture and response to psychostimulants differently.
T-type calcium channels are important in burst firing and expressed in brain regions implicated in schizophrenia. Therefore, we examined the effects of novel selective T-type calcium channel antagonists in preclinical assays predictive of antipsychotic-like activity. TTA-A2 blocked the psychostimulant effects of amphetamine and MK-801 and decreased conditioned avoidance responding.
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