Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review.

Background: In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychiatric conditions.

Aims: In light of these findings surrounding ketamine's psychotherapeutic potential, we systematically review the extant evidence on ketamine's effects in treating mental health disorders.

Method: The systematic review protocol was registered in PROSPERO (identifier CRD42019130636).