Publications by authors named "Shannon Dobres"
Article Synopsis
- Traumatic brain injury (TBI) leads to prolonged inflammation in the brain driven by microglia, which is worsened by stress and can disrupt sleep patterns.
- Exposure to sleep fragmentation (SF) after TBI was found to affect sleep and impair brain function, particularly in males, without worsening pre-existing sleep issues.
- At 30 days post-injury, mice that experienced SF stress showed increased inflammation, reduced neurogenesis, and altered gene expression related to synaptic function, indicating long-term effects on brain recovery.
Traumatic brain injury (TBI) is a complex and heterogeneous condition that can cause wide-spectral neurological sequelae such as behavioral deficits, sleep abnormalities, and post-traumatic epilepsy (PTE). However, understanding the interaction of TBI phenome is challenging because few animal models can recapitulate the heterogeneity of TBI outcomes. We leveraged the genetically diverse recombinant inbred Collaborative Cross (CC) mice panel and systematically characterized TBI-related outcomes in males from 12 strains of CC and the reference C57BL/6J mice.
View Article and Find Full Text PDF