Dexamethasone Intracanalicular Insert for Clinically Significant Aqueous-Deficient Dry Eye: A Randomized Controlled Trial.

Purpose: To evaluate a commercially available dexamethasone intracanalicular insert to treat dry eye.

Design: Single-center, double-masked randomized controlled trial.

Participants: Patients with clinically significant aqueous-deficient dry eye (combined ocular surface staining score, ≥ 3 [0-12]; corneal fluorescein staining score, ≥ 2 [0-6]; and Schirmer's wetting, < 10 mm at 5 minutes in both eyes) with symptoms (dryness, eye discomfort, or visual fatigue, ≥ 30 [0-100]) despite treatment with at least 1 prescription drop and deemed candidates for topical steroid therapy.

Racial and Ethnic Disparities in Dry Eye Diagnosis and Care.

Purpose: To investigate health disparities in racial and ethnic minorities with dry eye.

Methods: Medical records were reviewed for demographics, socioeconomic factors, treatments, and objective dry eye parameters. Race/ethnicity was self-reported as delineated by the U.

Outcomes of Sjögren's versus non-Sjögren's related dry eye in a longitudinal, tertiary clinic-based sample.

Purpose: To assess the long-term treatment outcomes of dry eye in patients with and without underlying primary Sjögren's syndrome (SS).

Design: Retrospective longitudinal cohort.

Methods: SS and non-SS dry eye patients with clinic visits for a minimum of 5 consecutive years at a tertiary, dedicated dry eye clinic were included.

Short-Term Clinical Outcomes of a Novel Corneal Prosthetic Device in a Rabbit Model.

Purpose: To evaluate the clinical performance and biocompatibility of a novel synthetic corneal device.

Methods: Synthetic, single-piece, foldable, suturable, optic-and-skirt design prototype devices were fabricated using expanded polytetrafluoroethylene. A combination of intralamellar and full-thickness penetrating techniques was used for implantation.

Long-term clinical outcomes of keratoplasty using gamma-irradiated corneal lenticules.

Objective: To report long-term clinical outcomes of gamma-irradiated corneal lenticules in partial and full-thickness keratoplasty.

Methods And Analysis: This multicentre, retrospective case series includes 23 patients who underwent surgery at three centres (India, Guatemala, and USA) between May 2009 and March 2018. The main outcome measures were epithelialization and retention for therapeutic keratoplasty and best spectacle-corrected visual acuity (BSCVA) for optical keratoplasty.