The role of molecular biomarkers in the diagnosis, prognosis, and treatment stratification of oral squamous cell carcinoma: A comprehensive review.

One of the most common cancers targeting the area of the head and neck is oral squamous cell carcinoma (OSCC), carrying a heavy global health cost. With a high incidence of metastasis and recurrence, the outlook for OSCC remains dismal despite advancements in treatment. This has sparked an investigation into molecular biomarkers, which have the potential to improve early diagnosis, forecast patient outcomes, and direct therapeutic approaches.

pH-responsive chitosan copolymer synthesized via click chemistry for design of polymeric nanoparticles for targeted drug delivery.

The polymeric nanoparticles (PNPs) loaded with prednisolone were developed to exhibit pH-responsive properties owing to the attachment of a hydrazone linkage between the copolymer chitosan and mPEG. In the diseased cellular environment, the hydrazone bond tends to break due to reduced pH, leading to the release of the drug from the PNPs at the required site of action. The fabricated PNPs exhibit spherical morphology, optimum size (∼200 nm), negative surface charge, and monodispersed particle size distribution.

Synthesis and characterization of cystamine conjugated chitosan-SS-mPEG based 5-Fluorouracil loaded polymeric nanoparticles for redox responsive drug release.

The principle objective of this study was to develop and characterize redox responsive polymeric nanoparticles (PNPs) as a stimuli responsive drug delivery system. The chitosan-cystamine-methoxy poly(ethylene glycol) (CH-SS-mPEG) copolymer was synthesized by conjugation of cystamine appended chitosan with carboxylic acid-terminated mPEG and characterized by FTIR, H NMR, XRD analysis and colorimetric assay. This copolymer could be formulated as 5-Fluorouracil (5-FU) loaded PNPs and the characteristics of PNPs were evaluated.

Anticonvulsant activity of fraction isolated from ethanolic extract of heartwood of Cedrus deodara.

The heartwood of Cedrus deodara is traditionally used for the treatment of neurological disorders in India. In this study, the compound 3,4-bis(3,4-dimethoxyphenyl) furan-2,5-dione (BDFD) isolated from the ethanolic extract of C. deodara was evaluated for its anticonvulsant activity.