Publications by authors named "Shankar Vallabhajolusa"
Introduction: Hypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition.
Methods: A cross-sectional study of 156 subjects who underwent positron emission tomography with PiB.
Reduced retention of Pittsburgh compound B in white matter lesions.
Eur J Nucl Med Mol Imaging
January 2015
Article Synopsis
- The study explores the use of Pittsburgh compound B (PiB) as a tracer for white matter (WM) pathology in both healthy and cognitively impaired individuals, focusing on its retention in normal-appearing WM (NAWM) and WM lesions (WML).
- Using FLAIR imaging, researchers segmented WML and NAWM in 73 elderly subjects and analyzed PiB PET images, finding that PiB retention was significantly lower in WML compared to NAWM (14.6% reduction overall).
- The results suggest that WML presence affects PiB binding signals in WM, indicating its potential for assessing WM pathology and warranting further investigation into the mechanisms behind PiB binding in WM.