Publications by authors named "Shankar S"

This review will provide new ideas for preserving fruits and decreasing fruit waste. This review outlines and evaluates research concerning postharvest fruit preservation employing antimicrobial strategies, which involve the integration of biological control alongside physical or chemical methods. The concurrent deployment of two or three of these techniques, particularly biological approaches, has demonstrated enhanced and synergistic antimicrobial outcomes in practical scenarios.

View Article and Find Full Text PDF

BCL2/adenovirus E1B 19-kDa protein-interacting protein 2 homolog (BNIP-H or Caytaxin), a pivotal adaptor protein that facilitates cerebellar cortex growth and synaptic transmission, is posttranslationally modified to regulate neuronal function. This study reports the ubiquitination of BNIP-H by Carboxyl terminus of Hsc70-Interacting Protein (CHIP), a U-box containing E3 ligase that is also regulated autoubiquitination. Specifically, it was observed that CHIP autoubiquitinated itself primarily at Lys23 and Lys31 .

View Article and Find Full Text PDF

Recognizing the factors that cause dysfunction within a team is crucial for many teams. Growing studies have investigated the factors that affect college students' performance. This study focuses on the association between dysfunctional teams and student team performance (TP), with the mediating effect of students' attitudes towards team assessment.

View Article and Find Full Text PDF

This article describes estimates of energy drink uptake using national-level data in the US and provides clinical strategies for evaluating patients with unhealthy energy drink consumption. Our approach is grounded in the paradigm of harm reduction, which supports incremental change while recognizing people's dignity, autonomy, individualism, and accountability.1 Rather than urge complete abstinence, we emphasize the importance of helping people understand energy drinks' potential harmful effects independently of whether individuals are ready to abstain from energy drinks.

View Article and Find Full Text PDF

Functional genomics with libraries of knockout alleles is limited to non-essential genes and convoluted by the potential accumulation of suppressor mutations in knockout backgrounds, which can lead to erroneous functional annotations. To address these limitations, we constructed genome-wide libraries of conditional alleles based on the auxin-inducible degron (AID) system for inducible degradation of AID-tagged proteins in the budding yeast Saccharomyces cerevisiae. First, we determined that N-terminal tagging is at least twice as likely to inadvertently impair protein function across the proteome.

View Article and Find Full Text PDF

Insulin is a pivotal peptide hormone essential for regulating glucose homeostasis. It has been known for over 100 years, but its production and purification methods are still under improvement. Escherichia coli based bacterial expression system is primarily used for insulin production.

View Article and Find Full Text PDF
Article Synopsis
  • The study was a retrospective cohort analysis aimed at assessing the impact of gabapentinoids on opioid use after anterior lumbar interbody fusion surgery.
  • While gabapentinoid treatment led to a slight 2.9% reduction in daily opioid consumption, it paradoxically increased the total duration and amount of opioids prescribed significantly (37.1% and 41.7%, respectively).
  • Additionally, the use of gabapentinoids was linked to higher risks of pain-related readmissions and potential drug abuse.
View Article and Find Full Text PDF

The rapid emergence of inflammatory bowel disease (IBD) in Asia in the last two decades is anticipated to pose significant challenges to the healthcare systems of developing countries including India. Several epidemiological factors in the Asia Pacific region have been explored as risk factors for the development of IBD. In this narrative review, we discuss the evolution of adult-onset and paediatric IBD in South Asia and India, in relation to the current global epidemiology, over the last decade.

View Article and Find Full Text PDF

Introduction: Aquaculture has been considered a major food-producing sector in the world during the last few decades. The foremost constraint in the development of aquaculture is bacterial disease control and management. Since various fish pathogens are resistant to conservative treatments, it is essential to screen new and effective alternative antibacterial agents.

View Article and Find Full Text PDF

In this article, we identify challenges in the complex interaction between artificial intelligence (AI) systems and society. We argue that AI systems need to be studied in their socio-political context to be able to better appreciate a diverse set of potential outcomes that emerge from long-term feedback between technological development, inequalities and collective decision-making processes. This means that assessing the risks from the deployment of any specific technology presents unique challenges.

View Article and Find Full Text PDF

This study explores a new eco-friendly approach for developing bioactive gelatin films using UV-C irradiation-induced photo-crosslinking. Riboflavin, a food-grade photoinitiator, was selected at an optimal concentration of 1.25% (/) for crosslinking gelatin under UV-C exposure for 4 to 22 min.

View Article and Find Full Text PDF

Studies of cue-outcome contingency learning demonstrate outcome-density effects: participants typically overestimate contingencies when the outcome event is relatively frequent. Equivalent cue-density effects occur, although these have been examined less often. Few studies have simultaneously examined both event density effects or have manipulated the presentation order of the events, limiting knowledge of whether these phenomena share underlying principles.

View Article and Find Full Text PDF

Pathogens can be collected from air and detected in samples by many methods. However, merely detecting pathogens does not answer whether they can spread disease. To fully assess health risks from exposure to airborne pathogens, the infectivity of those agents must be assessed.

View Article and Find Full Text PDF
Article Synopsis
  • Ocular surface disorder (OSD) is a complex eye issue typically diagnosed through methods like Schirmer's test and tear quality assessments, but the Schirmer's test can give misleading results due to irritation.
  • This study examined 100 eyes from 50 patients, analyzing the relationship between Schirmer's test results and the presence of Matrix Metalloproteinase 9 (MMP-9) in tears, a marker of dry eye disease severity.
  • Results indicated that higher MMP-9 correlates with increased severity of dry eye symptoms, suggesting that MMP-9 could enhance diagnostic accuracy for patients who don't yet show obvious symptoms.
View Article and Find Full Text PDF

Introduction: Very low birth weight (VLBW) infants have the highest rate of neonatal intensive care unit (NICU) admissions owing to the higher comorbidities associated with premature birth and long hospital stays. VLBW infants fed a bovine (BOV)-based diet have higher mortality rates, necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and other comorbidities than those fed 100% human milk-based products. This study aims to evaluate the budgetary impact of adopting an exclusive human milk diet (EHMD) instead of a BOV-based diet in VLBW infants from Al-Ain Hospital, Sheikh Shakhbout Medical City, and Dubai Health Authority (DHA) in the United Arab Emirates (UAE).

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to compare the compressive and tensile strength of two conventional glass ionomer cements, zirconia-reinforced GIC, and silver amalgam.
  • Eighty samples from four groups were tested for compressive strength (CS) and diametral tensile strength (DTS) using specific apparatus and standards.
  • Results showed that silver amalgam had the highest CS and DTS, while zirconia-reinforced GIC performed better than conventional GICs, suggesting it has superior mechanical properties, but further research is needed for long-term efficacy.
View Article and Find Full Text PDF

Regulatory B cells (Breg) are instrumental in protecting allografts in transplantation. Breg signatures are identified in operationally tolerant human kidney transplant recipients and can predict organ survival and acute rejection. Animal models of transplantation and autoimmunity support the use of Breg as an adoptive cellular therapy.

View Article and Find Full Text PDF