Publications by authors named "Shankar Mohan Singh"
In this study, we present antifungal susceptibility data of clinical and environmental isolates of Central Indian Cryptococcus neoformans (Serotype A, n = 8 and n = 50 respectively) and Cryptococcus gattii (Serotype B, n = 01 and n = 04 respectively). Susceptibilities to fluconazole, itraconazole and ketoconazole were determined by using NCCLS broth micro-dilution methodology. The total number of resistant strains for fluconazole in case of C.
View Article and Find Full Text PDFStructural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.
Line Cantin Frédérick Faucher Jean-François Couture Karine Pereira de Jésus-Tran Pierre Legrand Shankar Mohan Singh
J Biol Chem
October 2007
Article Synopsis
- Antiandrogens, used for treating androgen-dependent disorders, currently have weak binding affinity for the human androgen receptor (hAR), creating a need for more effective drugs.
- Researchers designed new compounds to block the repositioning of a key helix (H12) in the hAR, which affects its ability to activate gene transcription.
- By synthesizing and testing various 5alpha-dihydrotestosterone derivatives with different C18 chains, they found some potent antagonists and discovered critical interactions in the receptor's structure, providing insights for developing better antiandrogens.